ArticleThe Journal of biological chemistry2019
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Proteolytic shedding of the prion protein: Uncovering "new" biological implications of a conserved cleavage event.Neural regeneration research · 2026Article
- Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease.Journal of neurochemistry · 2025Review
- Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection.Nature communications · 2024Article
- Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.Acta neuropathologica · 2024Article
- Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition.Neuronal signaling · 2023Article
- Cellular prion protein offers neuroprotection in astrocytes submitted to amyloid β oligomer toxicity.Molecular and cellular biochemistry · 2023Article
- Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein.Cell and tissue research · 2023Review
- The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk.Frontiers in immunology · 2023Review
- Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.Frontiers in cellular neuroscience · 2023Article
- Prion Protein: The Molecule of Many Forms and Faces.International journal of molecular sciences · 2022Review
- Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance.Molecules (Basel, Switzerland) · 2022Review
- Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology.Frontiers in cell and developmental biology · 2022Review
- APP deficiency and HTRA2 modulates PrPBBA advances · 2022Article
- Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.Science advances · 2021Article
- Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner.Aging · 2021Article
- Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders.Molecular psychiatry · 2021Review
- Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction.Neuronal signaling · 2021Review
- Cellular prion protein activates Caspase 3 for apoptotic defense mechanism in astrocytes.Molecular and cellular biochemistry · 2021Article
- Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network.Neurochemical research · 2020Article
- Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells.eLife · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Heledd H Jarosz-GriffithsFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT.
Nicola J CorbettFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT.
Helen A RowlandFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT.
Kate FisherFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT.
Alys C JonesFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT.
Jennifer Baronthe Flow Cytometry Facility Laboratory, Faculty of Biology, Medicine, and Health, University of Manchester, CTF Building, Oxford Road, Manchester M13 9PT.
Gareth J Howellthe Flow Cytometry Facility Laboratory, Faculty of Biology, Medicine, and Health, University of Manchester, CTF Building, Oxford Road, Manchester M13 9PT.
Sally A Cowleythe Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE.
Satyan Chintawarthe Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, and.ORCID 0000-0003-3663-2328
M Zameel Caderthe Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, and.
Katherine A B KellettFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT.
Nigel M HooperFrom the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT, nigel.hooper@manchester.ac.uk.ORCID 0000-0002-5811-3484
Manchester Academic Health Science Centre · GBJohn Radcliffe Hospital · GBUniversity of Manchester · GBUniversity of Oxford · GB
Funding
Biotechnology and Biological Sciences Research CouncilMedical Research Council MC_EX_MR/N50192X/1Medical Research Council MC_PC_16033Medical Research Council MC_PC_16034Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/M024962/1Medical Research Council MR/M024997/1Medical Research Council MR/N013255/1Medical Research Council MR/N50192X/1Parkinson's UK J-0901Wellcome Trust
Abstract
The cellular prion protein (PrP
Indexed as
ADAM10 ProteinAlzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesBiopolymersCell Line, TumorEnzyme ActivationGene Knockdown TechniquesHumansInduced Pluripotent Stem CellsMembrane ProteinsPrion ProteinsProtein BindingProteolysisReactive Oxygen SpeciesADAM10 ProteinADAM10 protein, humanAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesBiopolymersMembrane ProteinsPrion ProteinsReactive Oxygen SpeciesAlzheimer diseaseamyloid-beta (AB)cell surface proteininduced pluripotent stem cell (iPS cell) (iPSC)metallopeptidase ADAM10neurodegenerative diseaseoxidative stressprionproteolytic shedding
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.