Evidence map›Paper›PMID 30872389›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Gellan Gum Based

Karthik Yadav Janga, Akshaya Tatke, Narendar Dudhipala, Sai Prachetan Balguri, Mohamed Moustafa Ibrahim, Doaa Nabih Maria, Monica M Jablonski, Soumyajit Majumdar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 71 citations in OpenAlex.

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  11. Lipid-Based Nanovesicular Drug Delivery Systems.Nanomaterials (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Karthik Yadav JangaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Akshaya TatkeDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Narendar DudhipalaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Sai Prachetan BalguriDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Mohamed Moustafa IbrahimDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Doaa Nabih MariaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Monica M JablonskiDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.).
Soumyajit MajumdarDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy (K.Y.J., A.T., N.D., S.P.B., S.M.), and Research Institute of Pharmaceutical Sciences (S.M.), University of Mississippi, Oxford, Mississippi; Department of Ophthalmology, University of Tennessee Health Science Center, Hamilton Eye Institute, Memphis, Tennessee (M.M.I., D.N.M., M.M.J.); and Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.M.I., D.N.M.) majumso@olemiss.edu.
Mansoura University · EGUniversity of Mississippi · USUniversity of Tennessee Health Science Center · US

Funding

Evaluation and Inhibition of Efflux Pumps Expressed on the Blood Ocular BarrierR01EY022120 · NEI · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2015 to 2018
$1.5M
NEI NIH HHS R01 EY022120
6 · The paper itself

Abstract

Short precorneal residence time and poor transocular membrane permeability are the major challenges associated with topical ocular drug delivery. In the present research, the efficiency of the electrolyte-triggered sol-to-gel-forming system of natamycin (NT) transfersomes was investigated for enhanced and prolonged ophthalmic delivery. Transfersomes were optimized by varying the molar ratios of phospholipid, sorbitan monostearate (Span) and tocopheryl polyethylene glycol succinate (TPGS). NT transfersome formulations (FNs) prepared with a 1:1 molar ratio of phospholipid-to-Span and low levels of TPGS showed optimal morphometric properties, and were thus selected to fabricate the in situ gelling system. Gellan gum-based (0.3% w/v) FN-loaded formulations (FNGs) immediately formed an in situ gel in the simulated tear fluid, with considerable viscoelastic characteristics. In vitro cytotoxicity in corneal epithelial cells and corneal histology studies demonstrated the ocular safety and cytocompatibility of these optimized formulations. Transcorneal permeability of NT from these formulations was significantly higher than in the control suspension. Moreover, the ocular disposition studies of NT, from the FNs and FNGs, in New Zealand male albino rabbits demonstrated the superiority of the electrolyte-sensitive FNGs in terms of NT delivery to the ocular tissues.

Indexed as

Administration, OphthalmicAdministration, TopicalAnimalsAnti-Bacterial AgentsCell LineCorneaDrug CompoundingDrug Delivery SystemsElasticityGelsHumansLiposomesMaleNatamycinPermeabilityPolysaccharides, BacterialAnti-Bacterial Agentsgellan gumGelsLiposomesNatamycinPolysaccharides, Bacterial

Identifiers

PMID30872389
PMCPMC6806353
OpenAlexW2920977270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.