Evidence map›Paper›PMID 30872365›Full record

ArticleHaematologica2019

Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome.

Marisa Benagiano, Maria Orietta Borghi, Jacopo Romagnoli, Michael Mahler, Chiara Della Bella, Alessia Grassi, Nagaja Capitani, Giacomo Emmi, Arianna Troilo, Elena Silvestri and 8 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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  7. Review
  8. Article
  9. Article
  10. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review).International journal of molecular medicine · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Cardiovascular disease in systemic lupus erythematosus.Rheumatology and immunology research · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Marisa BenagianoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Maria Orietta BorghiIRCCS, Istituto Auxologico Italiano, Laboratory of Immunorheumatology, Cusano Milanino, Italy.
Jacopo RomagnoliDepartment of Surgery, Rome Catholic University, Rome, Italy.
Michael MahlerInova Diagnostics La Jolla, La Jolla, CA, USA.
Chiara Della BellaDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alessia GrassiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Nagaja CapitaniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Giacomo EmmiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Arianna TroiloDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Elena SilvestriDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Lorenzo EmmiInternal Interdisciplinary Medicine, Lupus Clinic, AOU Careggi, Florence, Italy.
Heba AlnwaisriDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Jacopo BitettiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Simona TapinassiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Domenico PriscoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Cosima Tatiana BaldariDepartment of Life Sciences, University of Siena, Siena, Italy.
Pier Luigi MeroniIRCCS, Istituto Auxologico Italiano, Laboratory of Immunorheumatology, Cusano Milanino, Italy pierluigi.meroni@unimi.it.
Mario Milco D'EliosDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy mariomilco.delios@unifi.it delios@unifi.it.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Milan · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus is frequently associated with antiphospholipid syndrome. Patients with lupus-antiphospholipid syndrome are characterized by recurrent arterial/venous thrombosis, miscarriages, and persistent presence of autoantibodies against phospholipid-binding proteins, such as β2-Glycoprotein I. We investigated the cytokine production induced by β2-Glycoprotein I in activated T cells that infiltrate

Indexed as

AdultAntibodies, AntiphospholipidAntiphospholipid SyndromeAtherosclerosisAutoantibodiesbeta 2-Glycoprotein IFemaleFollow-Up StudiesHumansInflammationInterferon-gammaInterleukin-17Interleukin-21InterleukinsLupus Erythematosus, SystemicLymphocyte ActivationAntibodies, AntiphospholipidAutoantibodiesbeta 2-Glycoprotein IInterferon-gammaInterleukin-17Interleukin-21Interleukins

Identifiers

PMID30872365
PMCPMC6959190
OpenAlexW2921393834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.