Evidence map›Paper›PMID 30872336›Full record

ArticleBMJ case reports2019

Primary central nervous system plasmablastic lymphoma in an HIV-positive patient.

Ruben Rhoades, Jerald Gong, Neil Palmisiano, Onder Alpdogan

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ruben RhoadesDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-9638-0516
Jerald GongDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Neil PalmisianoDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Onder AlpdoganDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Thomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmablastic lymphoma (PBL) is a rare subtype of diffuse large B-cell lymphoma, highly associated with HIV and Epstein-Barr virus (EBV) infections. It commonly presents in extranodal sites, often an oral mass, but reports of primary central nervous system PBL (PCNSPBL) are exceedingly rare. Here, we report on a 33-year-old man with newly diagnosed HIV infection who presented with acute-onset unilateral visual disturbance and was found to have biopsy-proven PCNSPBL. The neoplastic cells displayed a plasmacytoid appearance, with the expression of CD38 and CD138, and were positive for EBV by in situ hybridisation for EBV-encoded RNA. Systemic workup revealed the presence of Kaposi sarcoma, but no evidence of lymphoma. He is currently being treated with high-dose methotrexate, as well as antiretroviral therapy for his HIV infection, and has achieved a complete response.

Indexed as

AdultAntimetabolites, AntineoplasticAntiretroviral Therapy, Highly ActiveCentral Nervous System NeoplasmsEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHIVHIV InfectionsHumansMaleMethotrexatePlasmablastic LymphomaRare DiseasesSarcoma, KaposiTreatment OutcomeAntimetabolites, AntineoplasticMethotrexateCNS cancerHIV / AIDSmalignant and benign haematology

Identifiers

PMID30872336
PMCPMC6424190
OpenAlexW2922085001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.