ReviewEMBO reports2019
Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response.
Review in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Identifying molecular signatures of parapneumonic effusion reveals HMGB2 as the disease progression biomarker.Respiratory research · 2026Article
- Review
- New insights into the integrative effects of resistance training at moderate altitude on systemic inflammation.European journal of applied physiology · 2025Article
- Lack of Hypoxia Inducible Factor-1α Influences on Macrophages Ability to Deal withJID innovations : skin science from molecules to population health · 2025Article
- How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia.Nature reviews. Immunology · 2025Review
- Article
- Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension.Respiratory research · 2024Review
- Acute physiological responses and muscle recovery in females: a randomised controlled trial of muscle damaging exercise in hypoxia.BMC sports science, medicine & rehabilitation · 2024Article
- Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Uridine Diphosphate Glucose (UDP-G) Activates Oxidative Stress and Respiratory Burst in Isolated Neutrophils.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway.Biomedicines · 2023Review
- STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia.Cell death discovery · 2023Article
- Moonlighting chromatin: when DNA escapes nuclear control.Cell death and differentiation · 2023Review
- Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments.Cell metabolism · 2023Article
- Unravelling the role of obesity and lipids during tumor progression.Frontiers in pharmacology · 2023Review
- The role of monocytes in thrombotic diseases: a review.Frontiers in cardiovascular medicine · 2023Review
- Peripheral and central macrophages in obesity.Frontiers in endocrinology · 2023Review
- The effect of HIF on metabolism and immunity.Nature reviews. Nephrology · 2022Review
- Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts.eLife · 2022Article
- Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism.Experimental biology and medicine (Maywood, N.J.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of transcription factors known as hypoxia-inducible factors (HIFs). The protein members of the HIF signalling pathway are critical regulators of both the innate and adaptive immune responses, and there is an increasing body of evidence to suggest that the elicited changes occur through cellular metabolic reprogramming. Here, we review the literature on innate immunometabolism to date and discuss the role of hypoxia in innate cell metabolic reprogramming, and how this determines immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.