Evidence map›Paper›PMID 30872216›Full record

ArticleIEEE transactions on bio-medical engineering2019

Deep Collaborative Learning With Application to the Study of Multimodal Brain Development.

Wenxing Hu, Biao Cai, Aiying Zhang, Vince D Calhoun, Yu-Ping Wang

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Confound Controlled Multimodal Neuroimaging Data Fusion and Its Application to Developmental Disorders.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2025
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  13. Review
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  15. Brain Functional Connectivity Analysis via Graphical Deep Learning.IEEE transactions on bio-medical engineering · 2022
    Article
  16. Article
  17. Article
  18. Impact ofFrontiers in aging neuroscience · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenxing Hu
Biao Cai
Aiying Zhang
Vince D Calhoun
Yu-Ping Wang

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI BEDRICK, EDWARD J · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Integration of brain imaging with genomic and epigenomic dataR01MH104680 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI CALHOUN, VINCE D, DENG, HONG-WEN · 2014 to 2017
$2.1M
Integration of fMRI imaging, genomics, network and biological knowledgeR01MH107354 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2015 to 2018
$1.9M
Integration of multiscale genomic data for comprehensive analysis of complex diseR01GM109068 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2014 to 2018
$1.6M
NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIGMS NIH HHS P20 GM103472NIGMS NIH HHS R01 GM109068NIMH NIH HHS R01 MH104680NIMH NIH HHS R01 MH107354NIMH NIH HHS R01 MH118695
6 · The paper itself

Abstract

objectiveMulti-modal functional magnetic resonance imaging has been widely used for brain research. Conventional data-fusion methods cannot capture complex relationship (e.g., nonlinear predictive relationship) between multiple data. This paper aims to develop a neural network framework to extract phenotype related cross-data relationships and use it to study the brain development.

methodsWe propose a novel method, deep collaborative learning (DCL), to address the limitation of existing methods. DCL first uses a deep network to represent original data and then seeks their correlations, while also linking the data representation with phenotypical information.

resultsWe studied the difference of functional connectivity (FCs) between different age groups and also use FCs as a fingerprint to predict cognitive abilities. Our experiments demonstrated higher accuracy of using DCL over other conventional models when classifying populations of different ages and cognitive scores. Moreover, DCL revealed that brain connections became stronger at adolescence stage. Furthermore, DCL detected strong correlations between default mode network and other networks which were overlooked by linear canonical correlation analysis, demonstrating DCL's ability of detecting nonlinear correlations.

conclusionThe results verified the superiority of DCL over conventional data-fusion methods. In addition, the stronger brain connection demonstrated the importance of adolescence stage for brain development. SIGNIFICANCE: DCL can better combine complex correlations between multiple data sets in addition to their fitting to phenotypes, with the potential to overcome the limitations of several current data-fusion models.

Indexed as

Deep LearningAdolescentAdultAlgorithmsBrainChildHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingYoung Adult

Identifiers

PMID30872216
PMCPMC8177041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.