ArticleMagnetic resonance imaging2019
Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems.
Abstract readMulticenter Study
In one paragraph
Article in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
12 citing papers in PubMed.
- Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting.BMC medicine · 2025Article
- Ultrahigh-field animal MRI system with advanced technological update.Npj imaging · 2024Article
- Automated quality control of small animal MR neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study.Magma (New York, N.Y.) · 2024Article
- Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats.Pharmaceutics · 2023Article
- Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI.Scientific reports · 2022Article
- Rapid MR relaxometry using deep learning: An overview of current techniques and emerging trends.NMR in biomedicine · 2022Review
- Regulation of Oxygen Homeostasis at the Intestinal Epithelial Barrier Site.International journal of molecular sciences · 2021Review
- Experimental Protocols for MRI Mapping of Renal TMethods in molecular biology (Clifton, N.J.) · 2021Article
- A novel gamma GLM approach to MRI relaxometry comparisons.Magnetic resonance in medicine · 2020Article
- Influence of water based embedding media composition on the relaxation properties of fixed tissue.Magnetic resonance imaging · 2020Article
- The influence of VEGFR-2 blockade and focused ultrasound blood-brain barrier opening on the glioma-immune landscape.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
John C WatertonBioxydyn Ltd, Manchester Science Park, Rutherford House, Pencroft Way, MANCHESTER M15 6SZ, United Kingdom; Centre for Imaging Sciences, Division of Informatics Imaging & Data Sciences, School of Health Sciences, Faculty of Biology Medicine & Health, University of Manchester, Manchester Academic Health Sciences Centre, MANCHESTER M13 9PL, United Kingdom. Electronic address: john.waterton@bioxydyn.com.
Catherine D G HinesMerck & Co., Inc., West Point, PA, United States of America. Electronic address: catherine.hines@merck.com.
Paul D HockingsAntaros Medical, BioVenture Hub, 43183 Mölndal, Sweden; MedTech West, Chalmers University of Technology, Gothenburg, Sweden. Electronic address: paul.hockings@antarosmedical.com.
Iina LaitinenSanofi-Aventis Deutschland GmbH, R&D TIM - Bioimaging Germany, Industriepark Höchst, D-65926 Frankfurt am Main, Germany. Electronic address: iina.laitinen@sanofi.com.
Sabina ZiemianBayer AG, Research and Development, Pharmaceuticals, MR and CT Contrast Media Research, Müllerstraße 178, D-13353 Berlin, Germany. Electronic address: sabina.ziemian@bayer.com.
Simon CampbellIn-Vivo Bioimaging UK, RD Platform Technology & Science, GSK Medicines Research Centre, Gunnels Wood Road, STEVENAGE, Hertfordshire, SG1 2NY, United Kingdom. Electronic address: simon.x.campbell@gsk.com.
Michael GottschalkLund University BioImaging Center, Klinikgatan 32, SE-222-42 Lund, Sweden. Electronic address: michael.gottschalk@med.lu.se.
Claudia GreenBayer AG, Research and Development, Pharmaceuticals, MR and CT Contrast Media Research, Müllerstraße 178, D-13353 Berlin, Germany. Electronic address: claudia.green@bayer.com.
Michael HaaseIn-Vivo Bioimaging UK, RD Platform Technology & Science, GSK Medicines Research Centre, Gunnels Wood Road, STEVENAGE, Hertfordshire, SG1 2NY, United Kingdom. Electronic address: michael.v.haase@gsk.com.
Katja HassemerSanofi-Aventis Deutschland GmbH, R&D TIM - Bioimaging Germany, Industriepark Höchst, D-65926 Frankfurt am Main, Germany. Electronic address: katja.hassemer@sanofi.com.
Hans-Paul JuretschkeSanofi-Aventis Deutschland GmbH, R&D TIM - Bioimaging Germany, Industriepark Höchst, D-65926 Frankfurt am Main, Germany.
Sascha KoehlerBruker BioSpin MRI GmbH, Rudolf-Plank-Straße 23, D-76275 Ettlingen, Germany. Electronic address: Sascha.Koehler@bruker.com.
William LloydCentre for Imaging Sciences, Division of Informatics Imaging & Data Sciences, School of Health Sciences, Faculty of Biology Medicine & Health, University of Manchester, Manchester Academic Health Sciences Centre, MANCHESTER M13 9PL, United Kingdom. Electronic address: william.lloyd@manchester.ac.uk.
Yanping LuoiSAT Discovery, Abbvie, 1 North Waukegan Road, North Chicago, IL, 60064-1802, United States of America. Electronic address: yanping.luo@abbvie.com.
Irma Mahmutovic PerssonDepartment of Translational Sciences, Medical Radiation Physics, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden. Electronic address: irma.mahmutovic_persson@med.lu.se.
James P B O'ConnorDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine & Health, University of Manchester, Manchester Academic Health Sciences Centre, MANCHESTER M20 4BX, United Kingdom. Electronic address: james.o'connor@manchester.ac.uk.
Lars E OlssonDepartment of Translational Sciences, Medical Radiation Physics, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden. Electronic address: lars_e.olsson@med.lu.se.
Kashmira PindoriaIn-Vivo Bioimaging UK, RD Platform Technology & Science, GSK Medicines Research Centre, Gunnels Wood Road, STEVENAGE, Hertfordshire, SG1 2NY, United Kingdom. Electronic address: kashmira.2.pindoria@gsk.com.
Jurgen E SchneiderLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom. Electronic address: J.E.Schneider@leeds.ac.uk.
Steven SourbronLeeds Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, LIGHT Labs, Clarendon Way, LEEDS LS2 9JT, United Kingdom. Electronic address: S.Sourbron@leeds.ac.uk.
Denise SteinmannSanofi-Aventis Deutschland GmbH, R&D TIM - Bioimaging Germany, Industriepark Höchst, D-65926 Frankfurt am Main, Germany. Electronic address: denise.steinmann@sanofi.com.
Klaus StrobelBruker BioSpin MRI GmbH, Rudolf-Plank-Straße 23, D-76275 Ettlingen, Germany. Electronic address: Klaus.Strobel@bruker.com.
Sirisha TadimallaLeeds Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, LIGHT Labs, Clarendon Way, LEEDS LS2 9JT, United Kingdom. Electronic address: S.Tadimalla@leeds.ac.uk.
Irvin TehLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom. Electronic address: I.Teh@leeds.ac.uk.
Andor VeltienRadboud university medical center, Radiology (766), P.O.Box 9101, 6500, HB, Nijmegen, the Netherlands. Electronic address: Andor.Veltien@radboudumc.nl.
Xiaomeng ZhangiSAT Discovery, Abbvie, 1 North Waukegan Road, North Chicago, IL, 60064-1802, United States of America. Electronic address: xiaomeng.zhang@abbvie.com.
Gunnar SchützBayer AG, Research and Development, Pharmaceuticals, MR and CT Contrast Media Research, Müllerstraße 178, D-13353 Berlin, Germany. Electronic address: gunnar.schuetz@bayer.com.
Funding
Biotechnology and Biological Sciences Research CouncilCancer Research UK 15267Cancer Research UK 22746
Abstract
backgroundMany translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R
objectiveTo assess R
methodsR
resultsCoV for day-to-day repeatability (N = 180 regions of interest) was 2.34% and for between-centre reproducibility (N = 9 centres) was 1.43%. Mostly, these do not propagate to biologically significant between-centre error, although a few R
interpretationWhile several factors affect the reproducibility of R
Indexed as
Magnetic Resonance ImagingPhantoms, ImagingAnimalsBiomarkersComputer SimulationImage Processing, Computer-AssistedMiceNickelOxygenProtonsRatsRegression AnalysisReproducibility of ResultsSepharoseWaterBiomarkersNickelOxygenProtonsSepharoseWaterBiomarkerError propagationHardware stabilityMRIPhantomRelaxation timeReproducibility
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.