Evidence map›Paper›PMID 30872149›Full record

GuidelineJournal of the American Academy of Dermatology2019

North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.

Ali Alikhan, Christopher Sayed, Afsaneh Alavi, Raed Alhusayen, Alain Brassard, Craig Burkhart, Karen Crowell, Daniel B Eisen, Alice B Gottlieb, Iltefat Hamzavi and 10 more

Abstract readPractice GuidelineReview
In one paragraph

Guideline in Journal of the American Academy of Dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Efficacy and safety of biologics for hidradenitis suppurativa: A network meta-analysis of phase III trials.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Pooled it
  2. Short-term efficacy of biologics in moderate-to-severe hidradenitis suppurativa: A systematic review and NMA.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Pooled it
  3. Australasian hidradenitis suppurativa management guidelines.The Australasian journal of dermatology · 2025
    Guideline
  4. Guideline
  5. Adherence to Hidradenitis Suppurativa Treatment.American journal of clinical dermatology · 2024
    Pooled it
  6. Pooled it
  7. Guideline
  8. The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Observational
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Ali AlikhanSutter Health, Sacramento, California.
Christopher SayedDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: christopher_sayed@med.unc.edu.
Afsaneh AlaviDepartment of Medicine, Division of Dermatology, University of Toronto, Toronto, Ontario, Canada.
Raed AlhusayenDepartment of Medicine, Division of Dermatology, University of Toronto, Toronto, Ontario, Canada.
Alain BrassardDepartment of Dermatology, University of California at Davis, Sacramento, California.
Craig BurkhartDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Karen CrowellHealth Sciences Library, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Daniel B EisenDepartment of Dermatology, University of California at Davis, Sacramento, California.
Alice B GottliebDepartment of Dermatology, Icahn School of Medicine at Mt Sinai Hospital, New York, New York.
Iltefat HamzaviDepartment of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Paul G HazenAssociates in Dermatology, Westlake, Ohio.
Tara JaleelDepartment of Dermatology, Duke University School of Medicine, Durham, North Carolina.
Alexa B KimballDepartment of Dermatology, Harvard Medical School, Boston, Massachusetts.
Joslyn KirbyDepartment of Dermatology, Penn State Hershey Medical Center, Hershey, Pennsylvania.
Michelle A LowesLaboratory for Investigative Dermatology, New York, New York.
Robert MichelettiDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Angela MillerDepartment of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Haley B NaikDepartment of Dermatology, University of California San Francisco, San Francisco, California.
Dennis OrgillDivision of Plastic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Yves PoulinCentre de Recherche Dermatologique du Quebec Metropolitain, Quebec City, Quebec, Canada.

Funding

Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Microbial Shifts and Immune Dysregulation in Hidradenitis Suppurativa PathogenesisK23AR074531 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAIK, HALEY · 2019 to 2023
$887k
NIAMS NIH HHS K23 AR074531
6 · The paper itself

Abstract

Hidradenitis suppurativa is a severe and debilitating dermatologic disease. Clinical management is challenging and consists of both medical and surgical approaches, which must often be combined for best outcomes. Therapeutic approaches have evolved rapidly in the last decade and include the use of topical therapies, systemic antibiotics, hormonal therapies, and a wide range of immunomodulating medications. An evidence-based guideline is presented to support health care practitioners as they select optimal medical management strategies and is reviewed in this second part of the management guidelines. A therapeutic algorithm informed by the evidence available at the time of the review is provided.

Indexed as

Androgen AntagonistsAnti-Bacterial AgentsHidradenitis SuppurativaImmunosuppressive AgentsAdministration, OralAdministration, TopicalCanadaEvidence-Based MedicineFemaleHumansInjections, IntralesionalMaleNorth AmericaPrognosisRisk AssessmentTreatment OutcomeAndrogen AntagonistsAnti-Bacterial AgentsImmunosuppressive Agentsacne inversaadalimumabbiomarkerscarbon dioxide laserclindamycincomorbiditiesertapenemfinasterideguidelineshidradenitis suppurativainfliximablaserlifestyle modificationmicrobiomeNd:YAGoral contraceptive pillsrifampinspironolactone

Identifiers

PMID30872149
PMCPMC9131892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.