Evidence map›Paper›PMID 30871857›Full record

ArticleTrends in microbiology2019

Influenza and Staphylococcus aureus Coinfection: TLR9 at Play.

Keer Sun, Dennis W Metzger

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Innate immune role of IL-6 in influenza a virus pathogenesis.Frontiers in cellular and infection microbiology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Keer SunDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5900, USA. Electronic address: Keer.Sun@unmc.edu.
Dennis W MetzgerDepartment for Immunology & Microbial Disease, Albany Medical College, Albany, NY, 12208, USA. Electronic address: Metzged@amc.edu.
Albany Medical Center Hospital · USUniversity of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial lung infections are frequent causes of mortality following influenza infection, but the fundamental mechanisms remain largely unknown. A new study by Martínez-Colón et al. (PLoS Pathog. 2019;15:e1007560) now suggests that influenza-induced immune suppression of Staphylococcus aureus is mediated by TLR9 signaling.

Indexed as

CoinfectionInfluenza, HumanMethicillin-Resistant Staphylococcus aureusOrthomyxoviridae InfectionsStaphylococcal InfectionsHumansMethicillinStaphylococcus aureusToll-Like Receptor 9MethicillinTLR9 protein, humanToll-Like Receptor 9coinfectioninfluenzaStaphylococcus aureus

Identifiers

PMID30871857
OpenAlexW2921689832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.