Evidence map›Paper›PMID 30871746›Full record

Observational studyThe American journal of cardiology2019

Relation of Pregnancy Loss to Risk of Cardiovascular Disease in Parous Postmenopausal Women (From the Women's Health Initiative).

Philip S Hall, Gregory Nah, Eric Vittinghoff, Donna R Parker, JoAnn E Manson, Barbara V Howard, Gloria E Sarto, Margery L Gass, Shawnita M Sealy-Jefferson, Elena Salmoirago-Blotcher and 5 more

Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in The American journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Article
  6. Effects of prior reproductive losses on risk of cardiovascular diseases within six months of a first live birth.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Article
  7. Review
  8. Article
  9. Update on sex specific risk factors in cardiovascular disease.Frontiers in cardiovascular medicine · 2024
    Review
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  11. Review
  12. Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 1 country.

Philip S HallNorth Carolina Heart & Vascular, UNC Rex Healthcare, Raleigh North Carolina. Electronic address: philip.hall@unchealth.unc.edu.
Gregory NahDivision of Cardiology, University of California, San Francisco, San Francisco California.
Eric VittinghoffDivision of Cardiology, University of California, San Francisco, San Francisco California.
Donna R ParkerDivision of Epidemiology, Brown University, Providence Rhode Island.
JoAnn E MansonDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston Massachusetts.
Barbara V HowardMedStar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Research, Hyattsville Maryland.
Gloria E SartoDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Margery L GassNorth American Menopause Society, Cleveland Ohio.
Shawnita M Sealy-JeffersonDivision of Epidemiology, The Ohio State University College of Public Health, Columbus Ohio.
Elena Salmoirago-BlotcherDivision of Epidemiology, Brown University, Providence Rhode Island; Centers for Behavioral and Preventive Medicine, The Miriam Hospital, and Department of Medicine, Brown University School of Medicine.
Marcia L StefanickDivision of Epidemiology, Stanford University, Stanford California.
Aladdin H ShadyabDivision of Epidemiology, University of California, San Diego, La Jolla California.
Linda V Van HornDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois.
Ki ParkDivision of Cardiology, University of Florida, Gainesville Florida.
Nisha I ParikhDivision of Cardiology, University of California, San Francisco, San Francisco California.
University of California, San Francisco · USBrown University · USBrigham and Women's Hospital · USMedStar Health · USNorth American Menopause Society · USNorthwestern University · USStanford University · USThe Ohio State University · USUniversity of California San Diego · USUniversity of Florida · USUniversity of North Carolina Health Care · USUniversity of Wisconsin–Madison · US

Funding

Pregnancy complications, future cardiovascular disease risk factors and cardiovasR21HL115398 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PARIKH, NISHA INDRAVADAN · 2013 to 2014
$446k
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R21 HL115398
6 · The paper itself

Abstract

Women with history of pregnancy loss (PL) have higher burden of cardiovascular disease (CVD) later in life, yet it is unclear whether this is attributable to an association with established CVD risk factors (RFs). We examined whether PL is associated with CVD RFs and biomarkers in parous postmenopausal women in the Women's Health Initiative, and whether the association between PL and CVD RFs accounted for the association between PL and incident CVD. Linear and logistic regressions were used to estimate associations between baseline history of PL and CVD RFs. Cox proportional hazards regression models were used to estimate the associations between baseline history of PL and incident CVD after adjustment for baseline RFs. Of 79,121 women, 27,272 (35%) had experienced PL. History of PL was associated with higher body mass index (p < 0.0001), hypertension (p < 0.0001), diabetes (p = 0.003), depression (p < 0.0001), and lower income (p < 0.0001), physical activity (p = 0.01), poorer diet (p < 0.0001), smoking (p < 0.0001), and alcohol use (p < 0.0001). After adjustment for CVD RFs, PL was significantly associated with incident CVD over mean follow up of 16 years (hazard ratio 1.11, 95% confidence interval 1.06 to 1.16). In conclusion, several CVD RFs are associated with PL, but they do not entirely account for the association between PL and incident CVD.

Indexed as

PostmenopauseWomen's HealthAbortion, SpontaneousCardiovascular DiseasesFemaleHumansIncidenceMiddle AgedPregnancyProspective StudiesRisk AssessmentRisk FactorsUnited States

Identifiers

PMID30871746
PMCPMC6488415
OpenAlexW2915180830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.