ReviewJournal of the American College of Cardiology2019
Autonomic Nervous System Dysfunction: JACC Focus Seminar.
Review in Journal of the American College of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
184 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects of Exercise on Autonomic Cardiovascular Function in Older Adults: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Blood pressure variability and its utility in acute disease and critical illness: a systematic review.BMC anesthesiology · 2025Pooled it
- The developments and emerging trends of Autonomic Nervous System Research in Arrhythmia: a bibliometric study from 2004 to 2024.Frontiers in neuroscience · 2025Pooled it
- Cardiac sympathetic hyperinnervation after myocardial infarction: a systematic review and qualitative analysis.Annals of medicine · 2023Pooled it
- Acute cocoa ingestion decreases spontaneous cardiac baroreflex sensitivity in healthy older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Trial
- A Nonrandomized Trial of the Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in Type 2 Diabetic Subjects.Journal of diabetes research · 2023Trial
- Comparison of TWA and PEP as indices of α2- and ß-adrenergic activation.Psychopharmacology · 2022Trial
- Cardiovascular Autonomic Neuropathy and Indices of Heart Failure in Type 2 Diabetes: The CANCAN Study.Diabetes, obesity & metabolism · 2026Article
- Markers of Autonomic Function and Cancer Mortality Risk in Healthy Adults.JACC. Advances · 2026Article
- Article
- Exercise Training and Heart Rate Variability: A Guided Optimization of Cardiorespiratory Fitness in Cardiometabolic Disease.Current atherosclerosis reports · 2026Review
- The utility of the T wave peak to T wave end interval to Q-T end interval ratio as a dynamic indicator of cardiac sympathetic activity: a preliminary study.Heart and vessels · 2026Article
- Catheter Ablation Outcomes in Electrical Storm Versus Non-Electrical Storm Ventricular Tachycardia: A Systematic Review and Meta-Analysis.Journal of arrhythmia · 2026Article
- Relationship between cerebral white matter hyperintensities and autonomic function in older individuals with cerebral small vessel disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation.The Journal of physiology · 2026Review
- Author Response to "Dysautonomia in Long COVID: Why Sex Differences Matter in Cardiovascular Risk Assessment".Clinical medicine & research · 2026Article
- Assessment of the cardiac vagal reflex: validation of the 4-s exercise test during simulated wheelchair propulsion.European journal of applied physiology · 2026Article
- Scar neuroma infiltration to treat post-surgical first bite syndrome.Interventional pain medicine · 2026Article
- Clinical, Neuropathic, and Sudomotor Correlates of Orthostatic Hypotension in Type 2 Diabetes: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The Impact of L Arginine's Anti-Apoptotic, Anti-Inflammatory, and Anti-Fibrotic Effects in Modulating Diabetic Cardiomyopathy: The Role of microRNA-155b in the Diagnosis of Diabetic Cardiomyopathy.International journal of molecular sciences · 2026Article
124 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Autonomic nervous system control of the heart is a dynamic process in both health and disease. A multilevel neural network is responsible for control of chronotropy, lusitropy, dromotropy, and inotropy. Intrinsic autonomic dysfunction arises from diseases that directly affect the autonomic nerves, such as diabetes mellitus and the syndromes of primary autonomic failure. Extrinsic autonomic dysfunction reflects the changes in autonomic function that are secondarily induced by cardiac or other disease. An array of tests interrogate various aspects of cardiac autonomic control in either resting conditions or with physiological perturbations from resting conditions. The prognostic significance of these assessments have been well established. Clinical usefulness has not been established, and the precise mechanistic link to mortality is less well established. Further efforts are required to develop optimal approaches to delineate cardiac autonomic dysfunction and its adverse effects to develop tools that can be used to guide clinical decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.