ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2019
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Isoniazid Preventive Therapy for Prevention of Tuberculosis among People Living with HIV in Ethiopia: A Systematic Review of Implementation and Impacts.International journal of environmental research and public health · 2022Pooled it
- Pooled it
- An evaluation of a choice architecture-based intervention on prescribing of TB preventive treatment to people living with HIV in southern Africa (the CAT study): a cluster-randomised trial.BMJ global health · 2025Trial
- Mid-level managers' perspectives on implementing isoniazid preventive therapy for people living with HIV in Ugandan health districts: a qualitative study.BMC health services research · 2024Trial
- Health care providers acceptance of default prescribing of TB preventive treatment for people living with HIV in Malawi: a qualitative study.BMC health services research · 2024Trial
- 'And the stick to fight TB is TPT': nurse-identified barriers and facilitators of tuberculosis preventive therapy implementation in rural South Africa.BMJ open respiratory research · 2025Article
- Choice-architecture TB preventive therapy prescribing for HIV patients in Mozambique.Public health action · 2025Article
- Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review.Drugs · 2025Review
- Innovations in TB Screening and Preventive Therapy Services for PLHIV in Yogyakarta City, Indonesia.Tropical medicine and infectious disease · 2025Article
- Facilitators and barriers to initiating and completing tuberculosis preventive treatment among children and adolescents living with HIV in Uganda: a qualitative study of adolescents, caretakers and health workers.AIDS research and therapy · 2024Article
- Supporting re-engagement with HIV services after treatment interruption in South Africa: a mixed method program evaluation of MSF's Welcome Service.Scientific reports · 2024Article
- Strengthening HIV and HIV co-morbidity care in low- and middle-income countries: insights from behavioural economics to improve healthcare worker behaviour.Journal of the International AIDS Society · 2023Article
- Incidence of active tuberculosis among people living with HIV receiving long-term antiretroviral therapy in high TB/HIV burden settings in Thailand: implication for tuberculosis preventive therapy.Journal of the International AIDS Society · 2022Article
- Isoniazid preventive therapy use among adult people living with HIV in Zimbabwe.International journal of STD & AIDS · 2021Article
- Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa.Global health action · 2021Article
- Choice architecture-based prescribing tool for TB preventive therapy: a pilot study in South Africa.Public health action · 2020Article
- Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
settingSixty-seven government health facilities providing tuberculosis (TB) and human immunodeficiency virus (HIV) services across Ethiopia.
objectiveTo examine clinician barriers to implementing isoniazid preventive therapy (IPT) among people living with HIV.
designA cross-sectional study to evaluate the provider-related factors associated with high IPT coverage at the facility level.
resultsOn bivariate analysis, the odds of high IPT implementation were lower when clinicians felt patients were negatively affected by the side effects of IPT (OR 0.18, 95%CI 0.04-0.81) and perceived that IPT increased multidrug-resistant TB (MDR-TB) rates (OR 0.66, 95%CI 0.44-0.98). The presence of IPT guidelines on site (OR 2.93, 95%CI 1.10-7.77) and TB-HIV training (OR 3.08, 95%CI 1.11-8.53) had a positive relationship with high IPT uptake. In the multivariate model, clinician's perception that active TB was difficult to rule out had a negative association with a high IPT rate (OR 0.93; 95%CI 0.90-0.95).
conclusionsClinician impression that ruling out active TB among HIV patients is difficult was found to be a significant barrier to IPT uptake. Continued advancement of IPT relies greatly on improving the ability of providers to determine IPT eligibility and more confidently care for patients on IPT. Improved clinician support and training as well as development of new TB diagnostic technologies could impact IPT utilization among providers.
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