Evidence map›Paper›PMID 30871665›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2019

Contacts of underserved tuberculosis patients have higher odds of TB disease in North West England: a cohort study.

T Wingfield, P MacPherson, P Sodha, A Tucker, J Mithoo, S B Squire, P Cleary

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Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

T WingfieldDepartment of Clinical Infection, Microbiology, and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, Public Health England Field Service North West, Liverpool, Tropical and Infectious Diseases Unit, Royal Liverpool Hospital, Liverpool, LIV-TB Collaboration and Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK, Social Medicine, Infectious Diseases and Migration Group, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
P MacPhersonLIV-TB Collaboration and Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK, HIV/TB Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
P SodhaLiverpool School of Medicine, Liverpool.
A TuckerPublic Health England Field Service North West, Liverpool, Centre for Epidemiology, University of Manchester, Manchester.
J MithooLIV-TB Collaboration and Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK, Institute of Psychology, Health and Society, University of Liverpool, Liverpool, UK.
S B SquireLIV-TB Collaboration and Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK.
P ClearyPublic Health England Field Service North West, Liverpool.

Funding

Department of HealthMedical Research Council MR/K007467/1Wellcome TrustWellcome Trust 206575/Z/17/ZWellcome Trust 209075/Z/17/Z
6 · The paper itself

Abstract

objectiveTo investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England.

designThis was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support).

resultsA total of 2139 cases and their 10 019 contacts met the eligibility criteria. Being a contact of a patient with smear-positive TB with high ECM or being of Black Caribbean ethnicity was independently associated with greater odds of active TB disease (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.2-8.7; ECM-3 vs. ECM-0, OR 2.2, 95%CI 1.01-5.0; Black Caribbean vs. White, OR 7.4, 95%CI 2.1-25). Being a contact of a patient with smear-positive TB or of Black Caribbean ethnicity was also independently associated with greater odds of tuberculous infection (smear-positive vs. smear-negative, OR 5.3, 95%CI 3.8-7.3; and Black Caribbean vs. White, OR 6.7, 95%CI 2.0-25).

conclusionsThe social complexity and ethnicity of patients were associated with tuberculous infection and TB disease in their contacts.

Indexed as

Contact TracingAdolescentAdultAgedChildChild, PreschoolCohort StudiesEnglandFemaleHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRacial Groups

Identifiers

PMID30871665
PMCPMC6421945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.