Evidence map›Paper›PMID 30871558›Full record

ArticleBMC medical genomics2019

The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins.

Daria N Kashirina, Andrew J Percy, Liudmila Kh Pastushkova, Christoph H Borchers, Kirill S Kireev, Vladimir A Ivanisenko, Alexey S Kononikhin, Eugene N Nikolaev, Irina M Larina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Medical genomics research at BGRS-2018.BMC medical genomics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Daria N KashirinaInstitute for Biomedical Problems - Russian Federation State Scientific Research Center of RAS, Moscow, Russia. daryakudryavtseva@mail.ru.
Andrew J PercyGenome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, Canada.
Liudmila Kh PastushkovaInstitute for Biomedical Problems - Russian Federation State Scientific Research Center of RAS, Moscow, Russia.
Christoph H BorchersGenome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, Canada.
Kirill S KireevYu.A.Gagarin Research and Test Cosmonaut Training Center, Star City, Moscow Region, Russia.
Vladimir A IvanisenkoInstitute of Cytology and Genetics of SB RAS, Novosibirsk, Russia.
Alexey S KononikhinInstitute for Biomedical Problems - Russian Federation State Scientific Research Center of RAS, Moscow, Russia.
Eugene N NikolaevV.L. Talrose Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Irina M LarinaInstitute for Biomedical Problems - Russian Federation State Scientific Research Center of RAS, Moscow, Russia.
Institute of Biomedical Problems · RUInstitute of Energy Problems of Chemical Physics · RUGagarin Research and Test Cosmonaut Training Center · RUGenome British Columbia · CASiberian Branch of the Russian Academy of Sciences · RUUniversity of Victoria · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe conditions of space flight have a significant effect on the physiological processes in the human body, yet the molecular mechanisms driving physiological changes remain unknown.

methodsBlood samples of 18 Russian cosmonauts who had conducted long-duration missions to the International Space Station were collected 30 days before launch and on the first and seventh days after landing.

resultsA panel of 125 proteins in the blood plasma was quantitated by a well-established and highly regarded targeted mass spectrometry approach. This method involves the monitoring of multiple reactions in conjunction with stable isotope-labeled standards at the University of Victoria - Genome BC Proteomics Centre.

conclusionsReduction of circulating plasma volume during space flight and activation of fluid retention at the final stage of the flight affect the changes in plasma protein concentrations present in the first days after landing. Using an ANOVA approach, it was revealed that only 1 protein (S100A9) reliably responded to space flight conditions. This protein plays an important role in the functioning of the endothelium and can serve as a marker for activation of inflammatory reactions. Concentrations of the proteins of complement, coagulation cascades, and acute phase reactants increase in the blood of cosmonauts as measured the first day after landing. Most of these proteins' concentrations continue to increase by the 7th day after space flight. Similar dynamics are observed for proteases and their inhibitors. Thus, there is a shift in proteolytic blood systems, which is necessary for the restoration of muscle tissue and maintenance of oncotic homeostasis.

Indexed as

Space FlightAdultBlood ProteinsCalgranulin BChromatography, High Pressure LiquidHumansIsotope LabelingMaleMass SpectrometryMiddle AgedProteomicsBlood ProteinsCalgranulin BS100A9 protein, humanBlood proteinsCosmonautsMass spectrometry

Identifiers

PMID30871558
PMCPMC6416832
OpenAlexW2921566927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.