Evidence map›Paper›PMID 30871391›Full record

ArticleJournal of the American Heart Association2019

Thoracic Aortic Dissection in Tetralogy of Fallot: A Review of the National Inpatient Sample Database.

Alexander C Egbe, Juan Crestanello, William R Miranda, Heidi M Connolly

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. The Weekend Effect on Outcomes for Type A Aortic Dissection Surgery: A Nationwide Analysis.Interdisciplinary cardiovascular and thoracic surgery · 2026
    Article
  3. Article
  4. Article
  5. Aortopathy in repaired tetralogy of Fallot and David procedure.Cardiovascular diagnosis and therapy · 2024
    Review
  6. Article
  7. Article
  8. Adult Congenital Heart Disease in the Emergency Department.Journal of personalized medicine · 2024
    Review
  9. Article
  10. Essentials of Imaging the Repaired Tetralogy of Fallot Patient.CJC pediatric and congenital heart disease · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexander C Egbe1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Juan Crestanello2 Department of Cardiovascular Surgery Mayo Clinic Rochester MN.
William R Miranda1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Heidi M Connolly1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.
Mayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

Ventricular and Pulmonary Vascular Reserve after the Fontan OperationK23HL141448 · NHLBI · MAYO CLINIC ROCHESTER · PI EGBE, ALEXANDER · 2018 to 2021
$693k
NHLBI NIH HHS K23 HL141448
6 · The paper itself

Abstract

Background Thoracic aortic aneurysm is common in patients with tetralogy of Fallot ( TOF ); the incidence of thoracic aortic dissection ( TAD ) is unknown, but generally considered to be uncommon. The purpose of this study was to determine incidence and risk factors for TAD in TOF patients. Methods and Results This work is a retrospective review of the National Inpatient Sample ( NIS ) database for cases of ascending TAD among all hospital admissions in adults with TOF , 2000-2014. Of 18 353 admissions in TOF patients, 11 (0.06%; 6 per 10 000 admissions) of these were TAD -related admissions. For the TAD -related admissions, mean age was 49.8±7.2 years; aortic surgical interventions were performed during 8 of the admissions, and overall in-hospital mortality was 45% (5 of 11). Risk factors associated with TAD -related admission were age >60 years (odds ratio, 2.41; 95% CI, 1.23-3.25; P=0.013), male sex ( odds ratio, 6.91; 95% CI, 4.85-8.54; P<0.001), and hypertension (odds ratio, 1.74; 95% CI, 1.06-3.19; P=0.037). Conclusions This is the first population-based study of TAD outcomes in patients with TOF , and it showed a low risk of TAD in this population. This has important clinical implication with regard to surveillance and surgical intervention. Given that prevalence of thoracic aortic aneurysm is higher in TOF patients compared with the general population; therefore, making clinical decisions based on outcomes data and practice guidelines derived from patients with degenerative and bicuspid aortic valve-related aortopathies may lead to overtreatment. Further studies are required to better understand the pathobiology of this disease in order to make evidence-based recommendations for surveillance and treatment.

Indexed as

AdultAortic Aneurysm, ThoracicAortic DissectionDatabases, FactualFemaleHospitalizationHospital MortalityHumansIncidenceInpatientsMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsTetralogy of Fallotaortic aneurysmtetralogy of Fallotthoracic aortic dissection

Identifiers

PMID30871391
PMCPMC6475048
OpenAlexW2920830458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.