ArticleMolecules (Basel, Switzerland)2019
Development of an Impedimetric Aptasensor for Label Free Detection of Patulin in Apple Juice.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Emerging nano sensing technologies for the detection of biological and chemical food toxins.RSC advances · 2025Review
- Smartphone-Controlled Aptasensor for Voltammetric Detection of Patulin in Apple Juice.Sensors (Basel, Switzerland) · 2024Article
- Impedimetric Polyaniline-Based Aptasensor for Aflatoxin BFoods (Basel, Switzerland) · 2023Article
- Comprehensive review on patulin andFrontiers in plant science · 2023Review
- New Horizons for MXenes in Biosensing Applications.Biosensors · 2022Review
- Article
- A Sensitive Aptasensor Using Biotin-Streptavidin System for Patulin Detection in Apple Juice.Biosensors · 2022Article
- Development of Electrochemical Aptasensor for Lung Cancer Diagnostics in Human Blood.Sensors (Basel, Switzerland) · 2021Article
- The Role of Aryldiazonium Chemistry in Designing Electrochemical Aptasensors for the Detection of Food Contaminants.Materials (Basel, Switzerland) · 2021Review
- The Existing Methods and Novel Approaches in Mycotoxins' Detection.Molecules (Basel, Switzerland) · 2021Review
- Electrochemical Aptasensors: Current Status and Future Perspectives.Diagnostics (Basel, Switzerland) · 2021Review
- MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications.Sensors (Basel, Switzerland) · 2020Review
- Flexible Screen Printed Aptasensor for Rapid Detection of Furaneol: A Comparison of CNTs and AgNPs Effect on Aptasensor Performance.Nanomaterials (Basel, Switzerland) · 2020Article
- Advances in Analysis and Detection of Major Mycotoxins in Foods.Foods (Basel, Switzerland) · 2020Review
- Carbon and Tin-Based Polyacrylonitrile Hybrid Architecture Solid Phase Microextraction Fiber for the Detection and Quantification of Antibiotic Compounds in Aqueous Environmental Systems.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present work, an aptasensing platform was developed for the detection of a carcinogenic mycotoxin termed patulin (PAT) using a label-free approach. The detection was mainly based on a specific interaction of an aptamer immobilized on carbon-based electrode. A long linear spacer of carboxy-amine polyethylene glycol chain (PEG) was chemically grafted on screen-printed carbon electrodes (SPCEs) via diazonium salt in the aptasensor design. The NH₂-modified aptamer was then attached covalently to carboxylic acid groups of previously immobilized bifunctional PEG to build a diblock macromolecule. The immobilized diblocked molecules resulted in the formation of long tunnels on a carbon interface, while the aptamer was assumed as the gate of these tunnels. Upon target analyte binding, the gates were assumed to be closed due to conformational changes in the structure of the aptamer, increasing the resistance to the charge transfer. This increase in resistance was measured by electrochemical impedance spectroscopy, the main analytical technique for the quantitative detection of PAT. Encouragingly, a good linear range between 1 and 25 ng was obtained. The limit of detection and limit of quantification was 2.8 ng L
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