Evidence map›Paper›PMID 30871182›Full record

ReviewMolecules (Basel, Switzerland)2019

Enantiomeric Recognition and Separation by Chiral Nanoparticles.

Ankur Gogoi, Nirmal Mazumder, Surajit Konwer, Harsh Ranawat, Nai-Tzu Chen, Guan-Yu Zhuo

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ankur GogoiDepartment of Physics, Jagannath Barooah College, Jorhat, Assam 785001, India. ankurgogoi@gmail.com.ORCID 0000-0001-6255-6862
Nirmal MazumderDepartment of Biophysics, School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. nirmaluva@gmail.com.
Surajit KonwerDepartment of Chemistry, Dibrugarh University, Dibrugarh, Assam 786004, India. surajitkonwer@dibru.ac.in.
Harsh RanawatDepartment of Biophysics, School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. harsh.ranawat@outlook.com.ORCID 0000-0002-4783-9001
Nai-Tzu ChenInstitute of New Drug Development, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan. ohnonancy@mail.cmu.edu.tw.ORCID 0000-0001-6660-7065
Guan-Yu ZhuoInstitute of New Drug Development, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan. zhuo0929@mail.cmu.edu.tw.ORCID 0000-0002-9813-2989

Funding

Ministry of Science and Technology, Taiwan 107-2112-M-039-001
6 · The paper itself

Abstract

Chiral molecules are stereoselective with regard to specific biological functions. Enantiomers differ considerably in their physiological reactions with the human body. Safeguarding the quality and safety of drugs requires an efficient analytical platform by which to selectively probe chiral compounds to ensure the extraction of single enantiomers. Asymmetric synthesis is a mature approach to the production of single enantiomers; however, it is poorly suited to mass production and allows for only specific enantioselective reactions. Furthermore, it is too expensive and time-consuming for the evaluation of therapeutic drugs in the early stages of development. These limitations have prompted the development of surface-modified nanoparticles using amino acids, chiral organic ligands, or functional groups as chiral selectors applicable to a racemic mixture of chiral molecules. The fact that these combinations can be optimized in terms of sensitivity, specificity, and enantioselectivity makes them ideal for enantiomeric recognition and separation. In chiral resolution, molecules bond selectively to particle surfaces according to homochiral interactions, whereupon an enantiopure compound is extracted from the solution through a simple filtration process. In this review article, we discuss the fabrication of chiral nanoparticles and look at the ways their distinctive surface properties have been adopted in enantiomeric recognition and separation.

Indexed as

Amino AcidsHumansLigandsMolecular StructureNanoparticlesStereoisomerismAmino AcidsLigandschiralitychiral ligandenantiomerenantiomeric recognitionenantiomeric separationracemic mixturesurface-modified nanoparticle

Identifiers

PMID30871182
PMCPMC6470864

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.