Evidence map›Paper›PMID 30871166›Full record

ReviewNutrients2019

Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome.

Abeer M Mahmoud, Mohamed M Ali

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 2 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 2 syntheses or guidelines pooled it, 241 citations in OpenAlex.

  1. Pooled it
  2. Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence.Autism research : official journal of the International Society for Autism Research · 2020
    Pooled it
  3. Trial
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Decoding the power of the microbiome in human health.Frontiers in cellular and infection microbiology · 2026
    Review
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  13. Review
  14. Article
  15. Article
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  19. Article
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Abeer M MahmoudDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St. (AHSB), Room 433, Chicago, IL 60612, USA. amahmo4@uic.edu.
Mohamed M AliDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W. Taylor St. (AHSB), Room 433, Chicago, IL 60612, USA. mali37@uic.edu.
University of Illinois Chicago · US

Funding

DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight LossK99HL140049 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MOHAMED, ABEER M · 2018 to 2019
$213k
NHLBI NIH HHS K99 HL140049NIH HHS 1K99HL140049-01
6 · The paper itself

Abstract

DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression. DNA methylation is modified by environmental factors such as diet that may modify cancer risk and tumor behavior. Abnormal DNA methylation has been observed in several cancers such as colon, stomach, cervical, prostate, and breast cancers. These alterations in DNA methylation may play a critical role in cancer development and progression. Dietary nutrient intake and bioactive food components are essential environmental factors that may influence DNA methylation either by directly inhibiting enzymes that catalyze DNA methylation or by changing the availability of substrates required for those enzymatic reactions such as the availability and utilization of methyl groups. In this review, we focused on nutrients that act as methyl donors or methylation co-factors and presented intriguing evidence for the role of these bioactive food components in altering DNA methylation patterns in cancer. Such a role is likely to have a mechanistic impact on the process of carcinogenesis and offer possible therapeutic potentials.

Indexed as

DNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMicronutrientsNeoplasmsNutritional StatusMicronutrientsbetainecancercholinedietaryDNA methylationfolatemethyl donorsmethyltransferasenutrientsVitamin B

Identifiers

PMID30871166
PMCPMC6471069
OpenAlexW2922188655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.