Evidence map›Paper›PMID 30871123›Full record

ArticleInternational journal of environmental research and public health2019

Prescription Infant Formulas Are Contaminated with Aluminium.

James Redgrove, Isabel Rodriguez, Subramanian Mahadevan-Bava, Christopher Exley

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Aluminum environmental pollution: the silent killer.Environmental science and pollution research international · 2021
    Review
  4. Determination of 40 Elements in Powdered Infant Formulas and Related Risk Assessment.International journal of environmental research and public health · 2021
    Article
  5. Impact of catch-up vaccination on aluminum exposure due to new laws and post social distancing.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James RedgroveLife Sciences, Huxley Building, Keele University, Staffordshire ST5 5BG, UK. jamesredgrove11@gmail.com.
Isabel RodriguezThe Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK. i.rodriguez.nunez-milara@keele.ac.uk.
Subramanian Mahadevan-BavaRussells Hall Hospital, Dudley Group Foundation NHS Trust, Pensnett Road, Dudley DY1 2HQ, West Midlands, UK. s.mahadevan@nhs.net.
Christopher ExleyThe Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK. c.exley@keele.ac.uk.ORCID 0000-0002-5116-7607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Historical and recent data demonstrate that off-the-shelf infant formulas are heavily contaminated with aluminium. The origin of this contamination remains to be elucidated though may be imported via ingredients, packaging and processing. Specialised infant formulas exist to address health issues, such as low birth weight, allergy or intolerance and medical conditions, such as renal insufficiency. The aluminium content of these prescription infant formulas is measured here for the first time. We obtained 24 prescription infant formulas through a paediatric clinic and measured their total aluminium content by transversely heated graphite furnace atomic absorption spectrometry following microwave assisted acid/peroxide digestion. The aluminium content of ready-to-drink formulas ranged from 49.9 (33.7) to 1956.3 (111.0) μg/L. The most heavily contaminated products were those designed as nutritional supplements for infants struggling to gain weight. The aluminium content of powdered formulas ranged from 0.27 (0.04) to 3.27 (0.19) μg/g. The most heavily contaminated products tended to be those addressing allergies and intolerance. Prescription infant formulas are contaminated with aluminium. Ready-made formulas available as nutritional supplements to aid infant growth contained some of the highest concentrations of aluminium in infant formulas measured in our laboratory. However, a number of prescription infant formulas contained the lowest concentrations of aluminium yet measured in our laboratory. These higher cost specialist preparations demonstrate that the contamination of infant formulas by aluminium is not inevitable. They represent what is achievable should manufacturers wish to address the threat posed to health through infant exposure to aluminium.

Indexed as

Food ContaminationAluminumHumansHypersensitivityInfantInfant FormulaInfant, NewbornSpectrophotometry, AtomicAluminumaluminium contaminationaluminium toxicityhuman exposure to aluminiuminfant formulasinfant nutirion

Identifiers

PMID30871123
PMCPMC6427753

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.