Evidence map›Paper›PMID 30871115›Full record

ArticleMolecules (Basel, Switzerland)2019

The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy.

Bo Wang, Liping Wang, Ying Peng, Yiying Pang, Hesheng Xiao, Xiaoji Wang, Shuangping Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bo WangSchool of Chemistry and Chemical Engineering, Jiangxi Science and Technology Normal University, Nanchang 330013, China. wbo0728@163.com.
Liping WangSchool of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China. wlping92@163.com.
Ying PengSchool of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China. dapengpeng@163.com.
Yiying PangSchool of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China. 13667080401@163.com.
Hesheng XiaoSchool of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China. xiaohes93@163.com.
Xiaoji WangSchool of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China. 2012207455@tju.edu.cn.
Shuangping HuangSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, China. hsping02@gmail.com.

Funding

National Science Foundation of China 21062088, 21562020Science and Technology Plan Project of Jiangxi Province 20151BBG70028, 20142BBE50006
6 · The paper itself

Abstract

Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner⁻Wadsworth⁻Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale.

Indexed as

Biological ProductsCatalysisMolecular StructurePlant ExtractsStereoisomerismBiological ProductsPlant ExtractssalvianolateDanshenHorner–Wadsworth–Emmons reactionmethyl salvianolate Asilyl protecting grouptotal synthesis

Identifiers

PMID30871115
PMCPMC6429350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.