Evidence map›Paper›PMID 30871102›Full record

ArticleInternational journal of molecular sciences2019

Comparable Genomic Copy Number Aberrations Differ across Astrocytoma Malignancy Grades.

Nives Pećina-Šlaus, Anja Kafka, Kristina Gotovac Jerčić, Monika Logara, Anja Bukovac, Robert Bakarić, Fran Borovečki

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. ITGB3BP is a potential biomarker associated with poor prognosis of glioma.Journal of cellular and molecular medicine · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nives Pećina-ŠlausLaboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine University of Zagreb, Šalata 12, 10000 Zagreb, Croatia. nina@mef.hr.ORCID 0000-0002-3334-7671
Anja KafkaLaboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine University of Zagreb, Šalata 12, 10000 Zagreb, Croatia. anja.kafka@mef.hr.
Kristina Gotovac JerčićDepartment for Functional Genomics, Center for Translational and Clinical Research, University of Zagreb, School of Medicine and University Hospital Center Zagreb, Šalata 2, 10000 Zagreb, Croatia. kristina.gotovac@mef.hr.
Monika LogaraGenom Ltd., Ilica 190, 10000 Zagreb, Croatia. monika.logara@gmail.com.
Anja BukovacLaboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine University of Zagreb, Šalata 12, 10000 Zagreb, Croatia. anja.bukovac@mef.hr.
Robert BakarićExaltum ultra Ltd.; Vrbik 13, 10000 Zagreb, Croatia. rbakaric@exaltum.eu.
Fran BorovečkiDepartment for Functional Genomics, Center for Translational and Clinical Research, University of Zagreb, School of Medicine and University Hospital Center Zagreb, Šalata 2, 10000 Zagreb, Croatia. fbor@mef.hr.
University of Zagreb · HRAsphalt Institute · USUniversity Hospital Centre Zagreb · HR

Funding

European Union through the European Regional Development Fund, Operational Programme Competitiveness and Cohesion, CoRE - Neuro. grant agreement No. KK.01.1.1.01.0007Hrvatska Zaklada za Znanost 6625 and 9386
6 · The paper itself

Abstract

A collection of intracranial astrocytomas of different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were analyzed by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Genomic Identification of Significant Targets in Cancer (GISTIC) 2.0.23 and DAVID software. Altogether, 1438 CNA were found of which losses prevailed. On our total sample, significant deletions affected 14 chromosomal regions, out of which deletions at 17p13.2, 9p21.3, 13q12.11, 22q12.3 remained significant even at 0.05

Indexed as

AdultAgedAstrocytomaCarcinogenesisChromosome AberrationsComparative Genomic HybridizationDNA Copy Number VariationsFemaleGenomicsHumansMaleMiddle AgedPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionYoung AdultPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktaCGHastrocytomacomparative genomic hybridizationcopy number aberrationsGISTIC2.0.23

Identifiers

PMID30871102
PMCPMC6429132
OpenAlexW2953228415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.