Evidence map›Paper›PMID 30871076›Full record

ArticleInternational journal of molecular sciences2019

Efficient Editing of the Nuclear

Daniel Guzmán-Zapata, José M Sandoval-Vargas, Karla S Macedo-Osorio, Edgar Salgado-Manjarrez, José L Castrejón-Flores, María Del Carmen Oliver-Salvador, Noé V Durán-Figueroa, Fabien Nogué, Jesús A Badillo-Corona

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 54 citations in OpenAlex.

  1. CRISPR-Cas Technology TurnsMarine drugs · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. PCD Genes-From Patients to Model Organisms and Back to Humans.International journal of molecular sciences · 2022
    Review
  7. Knockout ofJournal of genetics · 2022
    Article
  8. Review
  9. Article
  10. Establishment of a Genome Editing Tool Using CRISPR-Cas9 inInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Prospects for Engineering Biophysical COAnnual review of plant biology · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Frontiers in plant science · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Daniel Guzmán-ZapataInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. danielguza@gmail.com.
José M Sandoval-VargasInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. ibt_jose_sandoval@hotmail.com.
Karla S Macedo-OsorioInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. karla_032214@hotmail.com.
Edgar Salgado-ManjarrezInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. esalgado@ipn.mx.
José L Castrejón-FloresInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. jlcastrejon@ipn.mx.
María Del Carmen Oliver-SalvadorInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. moliver@ipn.mx.
Noé V Durán-FigueroaInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. nduranf@ipn.mx.
Fabien NoguéInstitut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, 78000 Versailles, France. fabien.nogue@inra.fr.ORCID 0000-0003-0619-4638
Jesús A Badillo-CoronaInstituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología. Av. Acueducto S/N., Col. Barrio La Laguna Ticomán, 07340 Mexico City, Mexico. jbadilloc@ipn.mx.ORCID 0000-0002-5409-5995
Instituto Politécnico Nacional · MXCentre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR11-BTBR-0001-GENIUSInstituto Politécnico Nacional 20180930
6 · The paper itself

Abstract

The clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9) technology is a versatile and useful tool to perform genome editing in different organisms ranging from bacteria and yeast to plants and mammalian cells. For a couple of years, it was believed that the system was inefficient and toxic in the alga

Indexed as

Adenine PhosphoribosyltransferaseChlamydomonas reinhardtiiClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated Protein 9CRISPR-Cas SystemsElectroporationGene EditingGenes, ReporterPlasmidsRibonucleoproteinsRNA, Guide, CRISPR-Cas SystemsAdenine PhosphoribosyltransferaseCRISPR-Associated Protein 9RibonucleoproteinsRNA, Guide, CRISPR-Cas Systemsadenine phosphoribosyl transferaseAPTCas9Chlamydomonas reinhardtiiCRISPR/Cas9glass beadsparticle bombardment

Identifiers

PMID30871076
PMCPMC6429146
OpenAlexW2922354312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.