ReviewPharmaceutics2019
Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation.
Review in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 169 citations in OpenAlex.
- Freeze-Dried CS/PVP/PVA Composite Scaffolds Doped with Curcumin and SiOInternational journal of molecular sciences · 2026Article
- Design, Synthesis and ROMP of NovelMaterials (Basel, Switzerland) · 2026Article
- Engineering a Bioactive PMMA-Silica Hybrid Scaffold for Enhanced Bone Regeneration.ACS applied bio materials · 2026Article
- Local Delivery of Genistein in Peri-Implant Defects Enhances Osseointegration in Ovariectomized Rats.Calcified tissue international · 2026Article
- Functionalization of Photocrosslinkable GelMA Hydrogel With Metal Oxides for Direct Pulp Capping.BioMed research international · 2026Article
- The Synergistic Effect of Polysaccharides and Silane Coupling Agents on the Properties of Calcium Phosphate-Based Bone Substitutes.International journal of molecular sciences · 2025Article
- Evaluating various properties of nanohydroxyapatite synthesized from eggshells and dual-doped with SiHeliyon · 2024Article
- Drug-Loaded Bioscaffolds for Osteochondral Regeneration.Pharmaceutics · 2024Review
- Exosomes: A New Hope for Angiogenesis-Mediated Bone Regeneration.International journal of molecular sciences · 2024Review
- 3D Printed SiOJournal of medicinal chemistry · 2024Article
- Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro.Bioengineering (Basel, Switzerland) · 2024Article
- Silica-associated proteins from hexactinellid sponges support an alternative evolutionary scenario for biomineralization in Porifera.Nature communications · 2024Article
- Neuro-bone tissue engineering: emerging mechanisms, potential strategies, and current challenges.Bone research · 2023Review
- The influence of silane coupling agents on the properties of α-TCP-based ceramic bone substitutes for orthopaedic applications.RSC advances · 2023Article
- Article
- Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts.Journal of functional biomaterials · 2023Article
- Dopamine-Assisted Modification of Polypropylene Film to Attain Hydrophilic Mineral-Rich Surfaces.Polymers · 2023Article
- Surface Biofunctionalization of Gadolinium Phosphate Nanobunches for Boosting Osteogenesis/Chondrogenesis Differentiation.International journal of molecular sciences · 2023Article
- Degradation of 3D-printed magnesium phosphate ceramicsBioactive materials · 2023Article
- Cytocompatible and osteoconductive silicon oxycarbide glass scaffolds 3D printed by DLP: a potential material for bone tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.