Evidence map›Paper›PMID 30871054›Full record

ArticleViruses2019

Quantifying Levels of Peste Des Petits Ruminants (PPR) Virus in Excretions from Experimentally Infected Goats and Its Importance for Nascent PPR Eradication Programme.

Satya Parida, M Selvaraj, S Gubbins, R Pope, A Banyard, Mana Mahapatra

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Satya ParidaThe Pirbright Institute, Ash Road, Woking, Surrey GU24 0NF, UK. satya.parida@pirbright.ac.uk.ORCID 0000-0001-8253-9461
M SelvarajThe Pirbright Institute, Ash Road, Woking, Surrey GU24 0NF, UK. Muni.NarayananSelvaraj@pirbright.ac.uk.
S GubbinsThe Pirbright Institute, Ash Road, Woking, Surrey GU24 0NF, UK. simon.gubbins@pirbright.ac.uk.ORCID 0000-0003-0538-4173
R PopeThe Pirbright Institute, Ash Road, Woking, Surrey GU24 0NF, UK. mitaliparida@yahoo.co.uk.
A BanyardAnimal and Plant Health Agency, Weybridge, Surrey KT15 3NB, UK. Ashley.Banyard@apha.gsi.gov.uk.
Mana MahapatraThe Pirbright Institute, Ash Road, Woking, Surrey GU24 0NF, UK. mana.mahapatra@pirbright.ac.uk.ORCID 0000-0002-3977-1465
The Pirbright Institute · GBAnimal and Plant Health Agency · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L004801/1Biotechnology and Biological Sciences Research Council BB/L013657/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/00007036Biotechnology and Biological Sciences Research Council BBS/E/I/00007037
6 · The paper itself

Abstract

Following the successful eradication of rinderpest, the World Organization of Animal Health (OIE) and the Food and Agriculture Organisation (FAO) have set a goal to globally eradicate Peste des petits ruminants (PPR) by 2030. To support the eradication programme we have quantified the levels of PPR virus (PPRV) nucleic acid excreted in body fluids (blood, feces, saliva, nasal and eye swabs) of PPRV-infected goats to ascertain which days post-infection animals are potentially infectious, and hence direct quarantine activities. The data will also indicate optimal sample strategies to assess presence of PPR infection in the naturally infected herd. Peak PPRV nucleic acid detection in different bodily fluids was between 5 and 10 days post-infection. As such, this period must be considered the most infectious period for contact transmission, although high viral load was observed through RNA detection in nasal excretions from two days post-infection until at least two weeks post-infection. Percentage sample positivity was low both in eye swabs and saliva samples during the early stage of infection although RNA was detected as late as two weeks post-infection. From the individual animal data, PPRV was detected later post-infection in fecal material than in other body fluids and the detection was intermittent. The results from this study indicate that nasal swabs are the most appropriate to sample when considering molecular diagnosis of PPRV.

Indexed as

Disease EradicationAnimalsDisease OutbreaksFecesGoat DiseasesGoatsMaleNosePeste-des-Petits-RuminantsPeste-des-petits-ruminants virusReal-Time Polymerase Chain ReactionRNA, ViralSalivaRNA, Viralbody excretionsmorbillivirusespeste des petits ruminantsreal-time RT-PCRviral nucleic acid detection

Identifiers

PMID30871054
PMCPMC6466160
OpenAlexW2338794927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.