Evidence map›Paper›PMID 30871038›Full record

ArticleJournal of clinical medicine2019

Acetazolamide Therapy in Patients with Heart Failure: A Meta-Analysis.

Janewit Wongboonsin, Charat Thongprayoon, Tarun Bathini, Patompong Ungprasert, Narothama Reddy Aeddula, Michael A Mao, Wisit Cheungpasitporn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Acetazolamide as an Adjunctive Diuretic Therapy for Patients with Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024 · on this map
    Pooled it
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  4. Diuretic Use in Heart Failure.Reviews in cardiovascular medicine · 2025
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  19. Acetazolamide for central sleep apnea: teaching an old drug new tricks?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Janewit WongboonsinDepartment of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. jwongboonsin@gmail.com.
Charat ThongprayoonDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA. charat.thongprayoon@gmail.com.
Tarun BathiniDepartment of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA. tarunjacobb@gmail.com.
Patompong UngprasertClinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. p.ungprasert@gmail.com.
Narothama Reddy AeddulaDivision of Nephrology, Department of Medicine, Deaconess Health System, Evansville, IN 47747, USA. dr.anreddy@gmail.com.ORCID 0000-0001-8530-668X
Michael A MaoDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA. mao.michael@mayo.edu.ORCID 0000-0003-1814-7003
Wisit CheungpasitpornDivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. wcheungpasitporn@gmail.com.ORCID 0000-0001-9954-9711
Mayo Clinic · USDeaconess Hospital · USSiriraj Hospital · THUniversity of Arizona · USUniversity of Minnesota · USUniversity of Mississippi Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesFluid overload and central sleep apnea are highly prevalent in patients with heart failure (HF). We performed this meta-analysis to assess the effects of acetazolamide therapy on acid/base balance and apnea indexes.

methodsA literature search was conducted using EMBASE, MEDLINE, and Cochrane Database from inception through 18 November 2017 to identify studies evaluating the use of acetazolamide in HF. Study results were analyzed using a random effects model. The protocol for this systematic review is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42017065401).

resultsNine studies (three randomized controlled trials and six cohort studies) with a total of 229 HF patients were enrolled. After acetazolamide treatment, there were significant decreases in serum pH (mean difference (MD) of -0.04 (95% CI, -0.06 to -0.02)), pCO₂ (MD of -2.06 mmHg (95% CI, -3.60 to -0.53 mmHg)), and serum bicarbonate levels (MD of -6.42 mmol/L (95% CI, -10.05 to -2.79 mmol/L)). When compared to a placebo, acetazolamide significantly increased natriuresis (standardized mean difference (SMD) of 0.67 (95% CI, 0.08 to 1.27)), and decreased the apnea-hypopnea index (AHI) (SMD of -1.06 (95% CI, -1.75 to -0.36)) and central apnea index (CAI) (SMD of -1.10 (95% CI, -1.80 to -0.40)). Egger's regression asymmetry tests revealed no publication bias with

conclusionOur study demonstrates significant reduction in serum pH, increase in natriuresis, and improvements in apnea indexes with use of acetazolamide among HF patients.

Indexed as

acetazolamidediureticsheart failuremeta-analysissleep apnea

Identifiers

PMID30871038
PMCPMC6463174
OpenAlexW2921592252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.