Trial reportNeurobiology of aging2019
Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification.
Trial report in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.Biological psychology · 2020Pooled it
- Effects of four-week intranasal oxytocin administration on large-scale brain networks in older adults.Neuropharmacology · 2024Trial
- Effects of chronic intranasal oxytocin on visual attention to faces vs. natural scenes in older adults.Psychoneuroendocrinology · 2024Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Safety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial.Psychopharmacology · 2021Trial
- Eye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces.Frontiers in endocrinology · 2021Trial
- Dynamic brain connectivity patterns induced by oxytocin: An fMRI Co-Activation pattern analysis study.Molecular psychiatry · 2026Article
- Single dose intranasal oxytocin administration: Data from healthy younger and older adults.Data in brief · 2023Article
- Oxytocin enhances the triangular association among behavior, resting-state, and task-state functional connectivity.Human brain mapping · 2023Article
- Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Associations between alcohol use and peripheral, genetic, and epigenetic markers of oxytocin in a general sample of young and older adults.Brain and behavior · 2022Article
- Oxytocin Release Increases With Age and Is Associated With Life Satisfaction and Prosocial Behaviors.Frontiers in behavioral neuroscience · 2022Article
- Age-Related Differences in Amygdala Activation Associated With Face Trustworthiness but No Evidence of Oxytocin Modulation.Frontiers in psychology · 2022Article
- Oxytocin's dynamic role across the lifespan.Aging brain · 2022Article
- A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing.Biology · 2021Review
- Age and intranasal oxytocin effects on trust-related decisions after breach of trust: Behavioral and brain evidence.Psychology and aging · 2021Article
- Chronic oxytocin administration in older men modulates functional connectivity during animacy perception.Aging brain · 2021Article
- The Role of Intranasal Oxytocin on Social Cognition: An Integrative Human Lifespan Approach.Current behavioral neuroscience reports · 2020Article
- Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.Psychoneuroendocrinology · 2019Article
- Musculoskeletal Pain and Brain Morphology: Oxytocin's Potential as a Treatment for Chronic Pain in Aging.Frontiers in aging neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
Aging is associated with increased difficulty in facial emotion identification, possibly due to age-related network change. The neuropeptide oxytocin (OT) facilitates emotion identification, but this is understudied in aging. To determine the effects of OT on dynamic facial emotion identification across adulthood, 46 young and 48 older participants self-administered intranasal OT or a placebo in a randomized, double-blind procedure. Older participants were slower and less accurate in identifying emotions. Although there was no behavioral treatment effect, partial least squares analysis supported treatment effects on brain patterns during emotion identification that varied by age and emotion. For young participants, OT altered the processing of sadness and happiness, whereas for older participants, OT only affected the processing of sadness (15.3% covariance, p = 0.004). Furthermore, seed partial least squares analysis showed that older participants in the OT group recruited a large-scale amygdalar network that was positively correlated for anger, fear, and happiness, whereas older participants in the placebo group recruited a smaller, negatively correlated network (7% covariance, p = 0.002). Advancing the literature, these findings show that OT alters brain activity and amygdalar connectivity by age and emotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.