ArticleCell host & microbe2019
Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses.
Open access · bronzeAbstract read
In one paragraph
Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.
0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 231 citations in OpenAlex.
- The gut microbiota as a regulator of intestinal stem-cell fate: bacterial and fungal control of differentiation and regeneration.Gut microbes · 2026Review
- Gut microbiome-enteric virus interactions: mechanisms, clinical implications, and translational directions.Journal of gastroenterology · 2026Review
- Review
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.iScience · 2026Article
- Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity.Mucosal immunology · 2026Article
- Gut commensal bifidobacteria are associated with restrained inflammatory reprogramming in human monocyte-derived dendritic cells.iScience · 2026Article
- Antibiotic-induced Malassezia expansion in the infant gut promotes early-life immune dysregulation and airway inflammation in mice.Nature communications · 2026Article
- Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.Cell reports. Medicine · 2026Article
- Devising a Zfu2p targeted antifungal strategy that may preserve commensalism while suppressing Candida albicans virulence during vulvovaginal candidiasis.Scientific reports · 2026Article
- Article
- An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans.Nature communications · 2026Article
- Article
- Resident microbes shape host immunity and protect against pathogen infection and inflammatory disease.Cellular and molecular life sciences : CMLS · 2026Review
- Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance.Nature communications · 2026Article
- Effect of the intestinal microbiota on TSeminars in immunopathology · 2026Review
- The role and possible mechanism of intestinal fungi in the progression of chronic liver diseases.NPJ biofilms and microbiomes · 2026Review
- Unraveling the dynamic changes in the intestinal microbiome: impacts on pre-weaning calf health and productivity.Journal of animal science and biotechnology · 2026Review
- Mycobiome dysbiosis and genetic predisposition to elevated IL-17A contribute to fibrosis in MASLD.JHEP reports : innovation in hepatology · 2026Article
- Untargeted Metabolomic Analysis of Cell-Free Supernatants (CFSs) from Different Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2026Article
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.bioRxiv : the preprint server for biology · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Tzu-Yu ShaoDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
W X Gladys AngDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Tony T JiangDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Felicia Scaggs HuangDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Heidi AndersenDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jeremy M KinderDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Giang PhamDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Ashley R BurgDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Brandy RuffDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Tammy GonzalezDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Gurjit K Khurana HersheyDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
David B HaslamDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Sing Sing WayDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: singsing.way@cchmc.org.
University of Cincinnati · USCincinnati Children's Hospital Medical Center · US
Funding
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MMedical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7MImmunological identity redefined by genetically foreign microchimeric cellsDP1AI131080 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$5.5MMaternal Regulatory T cell antigen-specificityR01AI120202 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$1.9MFunctional immune tolerance to non-inherited maternal antigenR01AI124657 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2017 to 2021
$1.9MSystemic immune modulation by enteric commensal fungiR21AI123089 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2017
$429kCommensal fungi positively calibrate asthma susceptibilityR21AI128932 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2017 to 2018
$429kAntifungal immunity controlled by commensal intestinal bacteria.F30DK107199 · NIDDK · UNIVERSITY OF CINCINNATI · PI JIANG, TIANLUN TONY · 2015 to 2018
$162kNIAID NIH HHS DP1 AI131080NIAID NIH HHS R01 AI120202NIAID NIH HHS R01 AI124657NIAID NIH HHS R21 AI123089NIAID NIH HHS R21 AI128932NIDDK NIH HHS F30 DK107199NIDDK NIH HHS P30 DK078392NIGMS NIH HHS T32 GM063483
Abstract
Mucosal barriers are densely colonized by pathobiont microbes such as Candida albicans, capable of invasive disseminated infection. However, systemic infections occur infrequently in healthy individuals, suggesting that pathobiont commensalism may elicit host benefits. We show that intestinal colonization with C. albicans drives systemic expansion of fungal-specific Th17 CD4
Indexed as
AnimalsCandida albicansCandidiasis, InvasiveCross ProtectionDisease Models, AnimalInterleukin-17Intestinal MucosaMiceOrthomyxoviridae InfectionsStaphylococcal InfectionsTh17 CellsInterleukin-17asthmaCD4 T cellscommensalfungiIL-17immunityinfectioninflammationneutrophilpathobiont
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.