Evidence map›Paper›PMID 30870619›Full record

ArticleCell host & microbe2019

Another Score for the Pore: S. aureus Leukocidins Take a Shot on the Endothelium.

Danielle N Alfano, Juliane Bubeck Wardenburg

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Value of heparin-binding protein in the diagnosis of severe infection in children: a prospective study.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Danielle N AlfanoDepartment of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8208, St. Louis, MO 63110, USA.
Juliane Bubeck WardenburgDepartment of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8208, St. Louis, MO 63110, USA. Electronic address: jbubeck@wustl.edu.
Washington University in St. Louis · US

Funding

Child Health Research CenterK12HD076224 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2013 to 2026
$6.2M
Role of Staphylococcus aureus alpha-hemolysin in diseaseR01AI097434 · NIAID · WASHINGTON UNIVERSITY · PI BUBECK WARDENBURG, JULIANE · 2012 to 2021
$4.0M
NIAID NIH HHS R01 AI097434NICHD NIH HHS K12 HD076224
6 · The paper itself

Abstract

Sepsis is a complex disease characterized by severe endothelial injury. In this issue of Cell Host & Microbe, Lubkin et al. (2019) reveal that an interaction between Staphylococcus aureus leukocidins and their cellular receptor DARC on endothelial cells leads to vascular injury, shedding light on pathogen-driven contributions to sepsis.

Indexed as

LeukocidinsStaphylococcal InfectionsAnimalsEndothelial CellsEndotheliumMiceStaphylococcus aureusLeukocidins

Identifiers

PMID30870619
OpenAlexW2922291431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.