SynthesisPloS one2019
Pneumonia-associated death in patients with dementia: A systematic review and meta-analysis.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dementia is a predictor for mortality outcome from coronavirus disease 2019 (COVID-19) infection.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study.Geriatric nursing (New York, N.Y.)Pooled it
- Vocal Fold Atrophy in an Alzheimer's Disease Rat Model.The Laryngoscope · 2026Article
- Factors associated with infection-related hospitalisations in severe mental illness: a retrospective cohort study.BMJ mental health · 2026Article
- Long-term Associations of Aspiration Pneumonia and All-Cause Mortality Following Percutaneous Endoscopic Gastrostomy : A US Multi-Institutional Retrospective Cohort Study.Journal of epidemiology and global health · 2026Article
- Serum vitamin B12 levels and 90-day outcomes in hospitalized patients with dementia: A cohort study.Medicine · 2026Article
- Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction.Communications biology · 2026Article
- Facility-Level Factors Associated With Aspiration Pneumonia in Japanese Geriatric Health Service Settings: A Nationwide Cross-Sectional Study.Geriatrics & gerontology international · 2026Observational
- Trends in mortality in elderly patients with Alzheimer's dementia and aspiration pneumonitis in the United States.Neurodegenerative disease management · 2026Article
- Demographic and geographic hotspots of Alzheimer's disease and pneumonia-related mortality among older adults in the United States: a retrospective analysis.European journal of medical research · 2026Article
- Evaluation of distinct and similar pathological features between diabetes and Alzheimer's disease.EXCLI journal · 2026Review
- The changing epidemiology of infection-associated mortality in Alzheimer's disease in the United States, 1999-2024.Frontiers in aging neuroscience · 2026Article
- Development and External Validation of an Explainable Machine Learning Model to Identify Positive Dysphagia Screening Results in People with Dementia: A Multicenter Cross-Sectional Study.Clinical interventions in aging · 2026Article
- Glycosphingolipids in Dementia: Insights from Mass Spectrometry and Systems Biology Approaches.Biomedicines · 2025Review
- Dementia Is Associated with In-Hospital Mortality and Prolonged Length of Stay: A Propensity Score Matched Analysis on Administrative Data.Healthcare (Basel, Switzerland) · 2025Article
- Association Between Cognitive Impairment and Poor Oral Function in Community-Dwelling Older People: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Health outcomes in chronic kidney disease patients with cognitive impairment or dementia: a global collaborative analysis.Clinical kidney journal · 2025Article
- Dementia, Systemic Biomarkers, and Risk of 30-Day Readmission After Pneumonia: A Multi-Center Cohort Study.International journal of general medicine · 2025Article
- A valuation based theory of learning's origin and development.Frontiers in systems neuroscience · 2025Article
- Dementia as a risk factor for 30-day mortality in community-acquired pneumonia in Colombia (CAP): A survival study.PloS one · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPneumonia is a serious disease associated with mortality among patients with dementia. However, the reported frequency of pneumonia as a cause of death in patients with dementia varies, the reason for which has not been fully elucidated.
methodsWe conducted a systematic search in PubMed and the Cochrane Database of Systematic Reviews (inception to December 2016). Two authors independently determined the suitability of studies and potential bias and extracted the data. The primary outcome was frequency of pneumonia-associated death in patients with dementia. Stratified subgroup analysis was conducted among studies grouped according to type of mortality cause (immediate or underlying), information source of mortality cause (autopsy or death certificate), and study setting (clinic, hospital, or nursing home).
resultsWe included 7 studies reporting the cause of death among patients with dementia and 12 studies comparing the cause of death among patients with and without dementia. The frequency of pneumonia-associated death among 19 eligible studies was 29.69% (95% confidence interval [CI], 25.86-33.53). Those frequencies differed according to whether the source for information about cause of death was an autopsy confirmation (49.98%; 95% CI, 43.75-56.71) or death certificate (19.65%; 95% CI, 15.48-23.83) and according to whether the type of mortality cause was an indirect cause of death (13.96%; 95% CI, 9.42-18.51) or direct cause of death (44.45%; 95% CI, 29.81-50.10). The risk of pneumonia-associated death in patients with dementia was twice as high as among those without dementia (odds ratio, 2.15; 95% CI, 1.63-2.83; p < 0.001).
conclusionThe various frequencies of pneumonia-associated death in patients with dementia were associated with the information source, type of mortality cause, and study setting. Patients with dementia in the terminal stages urgently require careful clinical management of pneumonia, to maximize patient life expectancy and quality.
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