ArticlePloS one2019
Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Outdoor residual spraying for malaria vector-control in Kayin (Karen) state, Myanmar: A cluster randomized controlled trial.PloS one · 2022Trial
- Mosquito vector composition and biting behavior of malaria vectors in forest versus humid savanna eco-epidemiological settings of Cameroon.Malaria journal · 2026Article
- The genomics of insecticide resistance in Anopheles funestus: insights from a large bed-net trial.BMC genomics · 2026Article
- Impact of insecticide resistance on controlling mosquito vectors and its potential contribution to behavioural modifications.Malaria journal · 2025Review
- Managing insecticide resistance in malaria vectors in Africa: case studies from Cameroon, Côte d'Ivoire and Tanzania.Malaria journal · 2025Article
- The duplicated cytochrome P450 CYP6P9a/b confers cross-resistance to a mitochondrial complex I inhibitor in the African malaria vector Anopheles funestus.BMC genomics · 2025Article
- Signatures of selection and mechanisms of insecticide resistance in UgandanbioRxiv : the preprint server for biology · 2025Article
- Article
- Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers.Pest management science · 2025Article
- Inheritance and Resistance Mechanisms of Field-Evolved Resistance to Pyrethroids in a Fall Armyworm (Insects · 2024Article
- Entomological longitudinal surveys in two contrasted eco-climatic settings in Cameroon reveal a high malaria transmission from Anopheles funestus associated with GSTe2 metabolic resistance.BMC infectious diseases · 2023Article
- High efficacy of chlorfenapyr-based net InterceptorInfectious diseases of poverty · 2023Article
- Impact of insecticide resistance on malaria vector competence: a literature review.Malaria journal · 2023Review
- Evolution of thePathogens (Basel, Switzerland) · 2022Article
- Reduced performance of community bednets against pyrethroid-resistant Anopheles funestus and Anopheles gambiae, major malaria vectors in Cameroon.Parasites & vectors · 2022Article
- Article
- The effect of blood feeding on insecticide resistance intensity and adult longevity in the major malaria vector Anopheles funestus (Diptera: Culicidae).Scientific reports · 2022Article
- Influence of a Major Mountainous Landscape Barrier (Mount Cameroon) on the Spread of Metabolic (Genes · 2020Article
- Quantifying late-stage host-seeking behaviour of Anopheles gambiae at the insecticidal net interface using a baited-box bioassay.Malaria journal · 2020Article
- Anopheles gambiae populations from Burkina Faso show minimal delayed mortality after exposure to insecticide-treated nets.Parasites & vectors · 2020Article
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9 authors.
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Abstract
backgroundDespite the increased report of insecticide resistance in malaria vectors, its impact on mosquito's life-traits after exposure to insecticide-treated nets remains under investigated. Here, we assessed the effects of exposure to PermaNet 2.0 on several life traits of An. gambiae s.l. and An. funestus s.l. field mosquitoes in Cameroon. METHODOLOGY: Female Anopheles mosquitoes were collected indoor using electric aspirators in southern Cameroon (Obout) in 2016. After assessing the resistance status of F1 from the field collected-mosquitoes, progeny of the first generation (An. funestus s.l.) and seventh generation (An. gambiae s.l.) were used to assess the long-term effect of exposure to PermaNet 2.0 on several life-traits of these vectors (longevity, blood feeding ability, fecundity and fertility) in comparison to untreated net. In addition, the L119F-GSTe2 mutation associated with DDT/pyrethroids resistance in An. funestus was genotyped to assess its association with increased life-span post-exposure. PRINCIPAL
findingsBoth An. funestus and An. gambiae were resistant to pyrethroids and DDT with a greater level in the latter. Pyrethroid-only nets PermaNet 2.0 (17.5% mortality) and Olyset (0% mortality) exhibited a significantly reduced efficacy against An. funestus in contrast to a greater efficacy for PBO-based Nets Olyset Plus (65% mortality), PermaNet 3.0 top (100% mortality). In both species, mosquitoes that survived exposure to PermaNet 2.0 exhibited a significantly reduced longevity than those non-exposed (6.95 days vs 12.46 for An. funestus P<0.001; 8.87 vs 11.25 days for An. gambiae; P<0.001). However, no significant difference was observed for blood feeding and fecundity in both species. In addition, molecular analysis of the L119F-GSTe2 mutation revealed that this mutation is associated with an increase in the chance of surviving after exposure to this net in An. funestus.
conclusionsThese results show that although the PermaNet 2.0 presents a reduced efficacy against resistant populations, it remains efficient after exposure by reducing the life expectancy of the vectors which could contribute in the reduction of malaria incidence.
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