ArticlePloS one2019
Mean platelet volume is more important than age for defining reference intervals of platelet counts.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Evaluation of Platelet Indices and Reticulated Platelets Using the ADVIA 2120 Analyzer in Patients with Acute Infection or Acute Coronary Syndrome, at Onset.Medical sciences (Basel, Switzerland) · 2025Article
- Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia.BMC psychiatry · 2025Article
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- Association betweenInternational journal of molecular sciences · 2024Article
- The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study.Journal of clinical medicine · 2023Article
- Association of the HALP Score with Dyslipidemia: A Large, Nationwide Retrospective Study.Medicina (Kaunas, Lithuania) · 2023Article
- Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort.Biology of sex differences · 2023Article
- Mean Platelet Volume as a Predictor of COVID-19 Severity: A Prospective Cohort Study in the Highlands of Peru.Diseases (Basel, Switzerland) · 2022Article
- Platelet size as a mirror for the immune response after SARS-CoV-2 vaccination.Journal of thrombosis and haemostasis : JTH · 2022Article
- Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus.Frontiers in medicine · 2021Article
- Reference Intervals for Platelet Counts in the Elderly: Results from the Prospective SENIORLAB Study.Journal of clinical medicine · 2020Article
- Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC).Journal of clinical medicine · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet counts and established individualized reference ranges respecting MPV.
methodsThe association of platelet count with age, sex and MPV was assessed in healthy participants (n = 3,033 individuals; 1,542 women) in the cross-sectional population-based cohort Study of Health in Pomerania. Reference intervals respecting age, sex, and MPV were estimated using quantile regressions for the 2.5th and 97.5th percentile.
resultsWomen had higher platelet counts than men (239 vs. 207 x109/L, p<0.001). Platelet counts correlated with age (p<0.001) and MPV (p<0.001). Quantile regression of lower and upper platelet count limits correlated less with age in female (p = 0.047 for 2.5th percentile; p = 0.906 for 97.5th percentile) and male subjects (p = 0.029 for 2.5th percentile; p = 0.195 for 97.5th percentile) compared to MPV (p<0.001 for upper and lower limit for both sexes). After adjustment for MPV, age did no longer correlate with the 2.5th (p = 0.165) or 97.5th percentile (p = 0.999) of platelet count. In contrast, after adjustment for age, MPV levels still significantly correlated with 2.5th, 50th and 97.5th percentile (p<0.001).
conclusionMPV and sex have a stronger association with platelet count than age. MPV should be considered to adjust platelet count reference intervals and needs to be respected as confounder for platelet counts in epidemiological studies and clinical practice.
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