Evidence map›Paper›PMID 30870215›Full record

ReviewExercise and sport sciences reviews2019

Resistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR.

Riki Ogasawara, Thomas E Jensen, Craig A Goodman, Troy A Hornberger

Open access · greenAbstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  8. Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Riki OgasawaraDepartment of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.
Thomas E JensenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
Craig A GoodmanInstitute of Health and Sport, Victoria University, Melbourne.
Troy A HornbergerDepartment of Comparative Biosciences, and.
Nagoya Institute of Technology · JPUniversity of Copenhagen · DKUniversity of Wisconsin–Madison · USVictoria University · AU

Funding

Mechanotransduction and the Regulation of Skeletal Muscle MassR01AR057347 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORNBERGER, TROY A · 2010 to 2019
$3.6M
Mechanotransduction and the Regulation of Skeletal Muscle MassR56AR057347 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORNBERGER, TROY A · 2022 to 2022
$270k
NIAMS NIH HHS R01 AR057347NIAMS NIH HHS R56 AR057347
6 · The paper itself

Abstract

The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

Indexed as

Resistance TrainingHumansMuscle ProteinsMuscle, SkeletalProteolysisSignal TransductionTOR Serine-Threonine KinasesMTOR protein, humanMuscle ProteinsTOR Serine-Threonine Kinases

Identifiers

PMID30870215
PMCPMC6659995
OpenAlexW2933360811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.