Evidence map›Paper›PMID 30869200›Full record

Trial reportJournal of the International AIDS Society2019

Perspectives of US women participating in a candidate PrEP study: adherence, acceptability and future use intentions.

K Rivet Amico, Catalina Ramirez, Margaret R Caplan, Brooke Ee Montgomery, Jennifer Stewart, Sally Hodder, Shobha Swaminathan, Jing Wang, Noshima Y Darden-Tabb, Marybeth McCauley and 6 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International AIDS Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

K Rivet AmicoUniversity of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-4458-6934
Catalina RamirezUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Margaret R CaplanDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Brooke Ee MontgomeryUniversity of Arkansas for Medical Sciences College of Public Health, Little Rock, AR, USA.
Jennifer StewartJohns Hopkins School of Nursing, Baltimore, MD, USA.
Sally HodderWest Virginia University School of Medicine, Morgantown, WV, USA.
Shobha SwaminathanRutgers New Jersey Medical School, Newark, NJ, USA.
Jing WangFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Noshima Y Darden-TabbUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Marybeth McCauleyFHI360, Washington, DC, USA.
Kenneth H MayerFenway Health and Harvard Medical School, New York, NY, USA.ORCID 0000-0001-8034-5110
Timothy WilkinWeill Cornell Medicine, New York, NY, USA.
Raphael J LandovitzDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Roy GulickWeill Cornell Medicine, New York, NY, USA.
Adaora A AdimoraUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
HPTN 069/A5305 Study Team and HPTN Women at Risk Committee
University of North Carolina at Chapel Hill · USCornell University · USUniversity of California, Los Angeles · USFamily Health International 360 · USFred Hutch Cancer Center · USHarvard University · USJohns Hopkins University · USRutgers, The State University of New Jersey · USUniversity of Arkansas for Medical Sciences · USUniversity of Michigan · USWest Virginia University · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
HIV Prevention trials Network (HPTN) Coordinating and Operations CenterU01AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI VERMUND, STEN H. · 2006 to 2010
$72.7M
University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit 2024 SupplementUM1AI069423 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, MINA CHRISTINE HOSSEINIPOUR · 2012 to 2026
$71.8M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002384NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1 RR024996NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI050410NIAID NIH HHS U01 AI068613NIAID NIH HHS U01 AI068617NIAID NIH HHS U01 AI068619NIAID NIH HHS U01 AI069412NIAID NIH HHS U01 AI069419NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069412NIAID NIH HHS UM1 AI069415NIAID NIH HHS UM1 AI069419NIAID NIH HHS UM1 AI069423NIAID NIH HHS UM1 AI069424NIAID NIH HHS UM1 AI069465NIAID NIH HHS UM1 AI069466NIAID NIH HHS UM1 AI069481NIAID NIH HHS UM1 AI069494NIAID NIH HHS UM1 AI069501NIAID NIH HHS UM1 AI069503NIAID NIH HHS UM1 AI069534NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

introductionLimited data exist on acceptability of candidate pre-exposure prophylaxis (PrEP) regimens among US women. We evaluated PrEP experiences, attitudes and future use intentions among sexually active women who completed the US-based HIV Prevention Trials Network 069/AIDS Clinical Trials Group 5305 study.

methodsWomen participated in the study between March 2013 and November 2015. We analysed computer-assisted self-interview (CASI) surveys among 130 women and conducted in-depth interviews among a subset of 26 women from three sites. Interviews were conducted in mid/late-2015.

resultsMost women (57%) reported very good/excellent PrEP adherence on CASI, although 21% acknowledged over-reporting adherence at least some of the time. Commitment to preventing HIV infection, a sense of ownership of the study, and keeping pills stored in a visible location facilitated adherence. Adherence barriers included "simply forgetting" and being away from home. Most women interviewed did not intend to use PrEP in the future because of lack of perceived need due to their own (as opposed to their partners') low-risk behaviour and concerns about affordability - but not because of side effects or other characteristics of the regimens. DISCUSSION: Improving HIV prevention options for US women will require access to affordable PrEP as well as expanding women's understanding of relationship- and community-level factors that increase their risk of acquiring HIV.

Indexed as

AdolescentAdultAnti-HIV AgentsFemaleHIV InfectionsHumansIntentionMiddle AgedPre-Exposure ProphylaxisProspective StudiesRisk-TakingSexual PartnersSurveys and QuestionnairesUnited StatesWomenYoung AdultAnti-HIV AgentsHIV preventionPrEPrisk perceptionUnited Stateswomen

Identifiers

PMID30869200
PMCPMC6416666
OpenAlexW2921251930

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.