ReviewEpidemiology and infection2019
The resurgence of syphilis in high-income countries in the 2000s: a focus on Europe.
Review in Epidemiology and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Prognostic effect of HIV on visual acuity in ocular syphilis: a systematic review.Eye (London, England) · 2023Pooled it
- Assessing complex interventions: a systematic review of outcomes used in randomised controlled trials on STI partner notification in high-income countries.BMC public health · 2023Pooled it
- Diagnostic tools for neurosyphilis: a systematic review.BMC infectious diseases · 2021Pooled it
- Trial
- Clearance ofEClinicalMedicine · 2026Article
- Syphilis and cerebral stroke: a case report and systematic review.Neurological research and practice · 2026Article
- Ocular Syphilis in the Era of Resurgence: Clinical Characteristics and Diagnostic Challenges in a Single-Center Cohort.Medicina (Kaunas, Lithuania) · 2026Article
- A challenging diagnosis of syphilis in a patient with a testicular lump: a case report.BMC infectious diseases · 2026Article
- Review
- Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.Journal of Korean medical science · 2026Article
- [Superbugs Neisseria gonorrhoeae und Mycoplasma genitalium : Therapeutic challenges driven by antimicrobial resistance].Dermatologie (Heidelberg, Germany) · 2026Review
- Discrepant treponemal test results: Identification of associated risk factors through machine learning technology in 18-year electronic medical records and national claims data.Biomedical journal · 2026Article
- Article
- Association of Psychoactive Substance Use With Syphilis and HIV Positivity Among Pregnant Women Receiving Prenatal Care in Belém, Northern Brazil.Journal of tropical medicine · 2026Article
- Epidemiological trends and spatiotemporal distribution of syphilis in Nagasaki Prefecture, Japan, 2014-2023.Frontiers in public health · 2026Article
- Increased transmission and incidence of syphilis in southern Sweden 2007-2022.Epidemiology and infection · 2025Article
- Serofast state after syphilis treatment: implications and recommendations for clinical practice. Narrative review.Postepy dermatologii i alergologii · 2025Review
- Hydrops Fetalis Caused by Congenital Syphilis: Case Series and a Comprehensive Review.Journal of clinical medicine · 2025Review
- Diagnostic riddle- case report of ocular syphilis.Journal of ophthalmic inflammation and infection · 2025Review
- Neonatal Outcomes of Mothers with Syphilis During Pregnancy: A Retrospective Single Center Experience.Children (Basel, Switzerland) · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis can cause severe complications and sequelae. Following a decrease in reported cases in European Union/European Economic Area (EU/EEA) and other high-income countries in the 1980s and 1990s as a result of the HIV epidemic and ensuing changes in sexual behaviour, trends started to increase in the 2000s in a number of EU/EEA Member States with higher rates among men and a large proportion of cases reported among men who have sex with men (MSM), particularly HIV-positive MSM. Trends in EU/EEA Member States vary however with some countries continuing to report decreases in the number of reported cases (mostly in the Eastern part of EU/EEA) whereas many Western European countries report increasing numbers of cases. Increasing rates among women, although still relatively low, have been observed in a number of countries leading to concerns around mother-to-child transmission of syphilis and congenital syphilis. Similar overall trends are observed in other high-income countries with the exception of Japan where rates among heterosexual men and women have been rising at alarming levels. Control of syphilis requires use of comprehensive, evidence-based strategies which take into account lessons learned from previous control efforts as well as consideration of biomedical interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.