Evidence map›Paper›PMID 30869021›Full record

ArticleEpidemiology and infection2019

Introduction of Ebola virus into a remote border district of Sierra Leone, 2014: use of field epidemiology and RNA sequencing to describe chains of transmission.

M B DeSilva, T Styles, C Basler, F L Moses, F Husain, M Reichler, S Whitmer, J McAuley, E Belay, M Friedman and 4 more

Abstract read
In one paragraph

Article in Epidemiology and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M B DeSilvaCenters for Disease Control and Prevention,Atlanta, Georgia,USA.ORCID 0000-0003-3705-1672
T StylesCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
C BaslerCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
F L MosesDistrict Medical Officer-Koinadugu, Ministry of Health and Sanitation,Kabala,Sierra Leone.
F HusainCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
M ReichlerCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
S WhitmerCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
J McAuleyCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
E BelayCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
M FriedmanCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
I S MuoghaluWorld Health Organization,Koinadugu,Sierra Leone.
P SwarayWorld Health Organization,Koinadugu,Sierra Leone.
U StröherCenters for Disease Control and Prevention,Atlanta, Georgia,USA.
J T ReddCenters for Disease Control and Prevention,Atlanta, Georgia,USA.

Funding

World Health Organization 001
6 · The paper itself

Abstract

In early October 2014, 7 months after the 2014-2015 Ebola epidemic in West Africa began, a cluster of reported deaths in Koinadugu, a remote district of Sierra Leone, was the first evidence of Ebola virus disease (Ebola) in the district. Prior to this event, geographic isolation was thought to have prevented the introduction of Ebola to this area. We describe our initial investigation of this cluster of deaths and subsequent public health actions after Ebola was confirmed, and present challenges to our investigation and methods of overcoming them. We present a transmission tree and results of whole genome sequencing of selected isolates to identify the source of infection in Koinadugu and demonstrate transmission between its villages. Koinadugu's experience highlights the danger of assuming that remote location and geographic isolation can prevent the spread of Ebola, but also demonstrates how deployment of rapid field response teams can help limit spread once Ebola is detected.

Indexed as

EbolavirusHemorrhagic Fever, EbolaSequence Analysis, RNASierra LeoneEbola virusoutbreakspublic health

Identifiers

PMID30869021
PMCPMC6518841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.