ArticleProceedings of the National Academy of Sciences of the United States of America1986
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site.iScience · 2025Article
- Function-based mutation-resistant synthetic signaling device activated by HIV-1 proteolysis.ACS synthetic biology · 2015Article
- Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins.Clinical epigenetics · 2015Article
- Association of goat (Capra hircus) CD4 gene exon 6 polymorphisms with ability of sperm internalizing exogenous DNA.Molecular biology reports · 2011Article
- Cell-surface receptors for retroviruses and implications for gene transfer.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Article
- Possible association of CD3 and CD4 polymorphisms with insulin-dependent diabetes mellitus (IDDM).Clinical and experimental immunology · 1994Article
- A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Adhesion molecules and transplantation.Annals of surgery · 1994Review
- Selection of rabbit CD4- CD8- T cell receptor-gamma/delta cells by in vitro transformation with human T lymphotropic virus-I.The Journal of experimental medicine · 1993Article
- Mouse chromosome 6.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8.Journal of virology · 1991Article
- Pentanucleotide repeat length polymorphism at the human CD4 locus.Nucleic acids research · 1991Article
- Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2.Journal of virology · 1991Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- LAG-3, a novel lymphocyte activation gene closely related to CD4.The Journal of experimental medicine · 1990Article
- Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14.Human genetics · 1990Article
- Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
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Authors and funding
6 authors.
Funding
Abstract
The surface glycoproteins T4 and T8 define functionally distinct populations of T lymphocytes. We have obtained cDNA and genomic clones encoding the T4 molecule and used these as probes to determine the chromosomal location of this gene. Genomic blotting experiments, along with in situ hybridization analyses, indicate that the T4 gene resides on the short arm of human chromosome 12, at region p12-pter. Thus, the T4 gene is not linked to any known member of the immunoglobulin gene family, including its counterpart gene, T8, which resides on human chromosome 2 immediately distal to the immunoglobulin kappa locus.
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