Evidence map›Paper›PMID 30868803›Full record

ArticleJournal of biomedical optics2019

Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography.

Jianbo Tang, Sefik Evren Erdener, Smrithi Sunil, David A Boas

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  13. Neurophotonics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianbo TangBoston University, Neurophotonics Center, Department of Biomedical Engineering, Boston, Massachusett, United States.
Sefik Evren ErdenerBoston University, Neurophotonics Center, Department of Biomedical Engineering, Boston, Massachusett, United States.
Smrithi SunilBoston University, Neurophotonics Center, Department of Biomedical Engineering, Boston, Massachusett, United States.
David A BoasBoston University, Neurophotonics Center, Department of Biomedical Engineering, Boston, Massachusett, United States.

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2M
Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular ChangesR01EB021018 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2015 to 2018
$2.9M
NIBIB NIH HHS R01 EB021018NIMH NIH HHS R01 MH111359NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS108472
6 · The paper itself

Abstract

Optical coherence tomography angiography (OCTA) has been widely used for en face visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the "tail" artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (g1-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating arterioles from venules in the 3-D image. g1   (  τ  )   is calculated from repeated optical coherence tomography (OCT) acquisitions for each spatial location. The decay amplitude of g1   (  τ  )   is retrieved to represent the dynamics for each voxel. To account for the small g1   (  τ  )   decay in capillaries where red blood cells are flowing slowly and discontinuously, Intralipid is injected to enhance the OCT signal. We demonstrate that the proposed technique realizes 3-D OCTA with negligible tail projections and the penetrating arteries are readily identified. In addition, compared to regular OCTA, the proposed g1-OCTA largely increased the depth-of-field. This technique provides a more accurate rendering of the vascular 3-D anatomy and has the potential for more quantitative characterization of vascular networks.

Indexed as

AnimalsBrainCerebral AngiographyImaging, Three-DimensionalMiceSignal-To-Noise RatioTomography, Optical Coherencenormalized autocorrelation functionoptical coherence tomography angiographythree-dimensional vascular imagingvessel tail artifacts

Identifiers

PMID30868803
PMCPMC6414735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.