ArticleInternational wound journal2019
Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo.
Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta-analysis of comparative clinical trials.International wound journal · 2021Pooled it
- An Antimicrobial Blue Light Prototype Device Controls Infected Wounds in a Preclinical Porcine Model.The Journal of infectious diseases · 2025Article
- A surfactant-based dressing can reduce the appearance of Pseudomonas aeruginosa pigments and uncover the dermal extracellular matrix in an ex vivo porcine skin wound model.International wound journal · 2024Article
- Biofilm-Associated Infections in Chronic Wounds and Their Management.Advances in experimental medicine and biology · 2023Article
- Activity of a hypochlorous acid-producing electrochemical bandage as assessed with a porcine explant biofilm model.Biotechnology and bioengineering · 2023Article
- Efficacy and toxicity of hydrogen peroxide producing electrochemical bandages in a porcine explant biofilm model.Journal of applied microbiology · 2022Article
- Controlled-release iodine foam dressings demonstrate broad-spectrum biofilm management in several in vitro models.International wound journal · 2022Article
- Robbing Peter to Pay Paul: Chlorhexidine gluconate demonstrates short-term efficacy and long-term cytotoxicity.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- Comparison of the Outcomes of Cadexomer Iodine and Povidone-Iodine Ointments in Wound Management.Cureus · 2022Article
- Topical Management of Wound: A Narrative Review of Cadexomer Iodine Ointment Versus Povidone Iodine Ointment.Cureus · 2022Review
- A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model.Regenerative biomaterials · 2021Article
- Biofilms in Diabetic Foot Ulcers: Impact, Risk Factors and Control Strategies.International journal of molecular sciences · 2021Review
- Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms.The ISME journal · 2021Article
- Article
- Evidence-Based Review of Antibiofilm Agents for Wound Care.Advances in wound care · 2021Review
- Bacterially sensitive nanoparticle-based dissolving microneedles of doxycycline for enhanced treatment of bacterial biofilm skin infection: A proof of concept study.International journal of pharmaceutics: X · 2020Article
- Clinical impact of an anti-biofilm Hydrofiber dressing in hard-to-heal wounds previously managed with traditional antimicrobial products and systemic antibiotics.Burns & trauma · 2020Article
- Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo.International wound journal · 2019Article
- Development of Rapid and Economic In Vitro Assay and Biorelevant Ex Vivo Biofilm Inhibition Wound Model to Test the Antibacterial Efficacy of Wound Dressings.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Biofilms are prevalent in non-healing chronic wounds and implicated in delayed healing. Tolerance to antimicrobial treatments and the host's immune system leave clinicians with limited interventions against biofilm populations. It is therefore essential that effective treatments be rigorously tested and demonstrate an impact on biofilm across multiple experimental models to guide clinical investigations and protocols. Cadexomer iodine has previously been shown to be effective against biofilm in various in vitro models, against methicillin-resistant Staphylococcus aureus biofilm in mouse wounds, and clinically in diabetic foot ulcers complicated by biofilm. Similarities between porcine and human skin make the pig a favoured model for cutaneous wound studies. Two antiseptic dressings and a gauze control were assessed against mature biofilm grown on ex vivo pig skin and in a pig wound model. Significant reductions in biofilm were observed following treatment with cadexomer iodine across both biofilm models. In contrast, silver carboxymethylcellulose dressings had minimal impact on biofilm in the models, with similar results to the control in the ex vivo model. Microscopy and histopathology indicate that the depth of organisms in wound tissue may impact treatment effectiveness. Further work on the promising biofilm efficacy of cadexomer iodine is needed to determine optimal treatment durations against biofilm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.