Evidence map›Paper›PMID 30868703›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Quantitative multivoxel proton MR spectroscopy for the identification of white matter abnormalities in mild traumatic brain injury: Comparison between regional and global analysis.

Matthew S Davitz, Oded Gonen, Assaf Tal, James S Babb, Yvonne W Lui, Ivan I Kirov

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Matthew S DavitzCenter for Advanced Imaging Innovation and Research (CAI2R), Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, Department of Radiology, New York, New York, USA.
Oded GonenCenter for Advanced Imaging Innovation and Research (CAI2R), Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, Department of Radiology, New York, New York, USA.
Assaf TalDepartment of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
James S BabbCenter for Advanced Imaging Innovation and Research (CAI2R), Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, Department of Radiology, New York, New York, USA.
Yvonne W LuiCenter for Advanced Imaging Innovation and Research (CAI2R), Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, Department of Radiology, New York, New York, USA.
Ivan I KirovCenter for Advanced Imaging Innovation and Research (CAI2R), Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, Department of Radiology, New York, New York, USA.ORCID 0000-0001-5641-8578
Advanced Imaging Research (United States) · USWeizmann Institute of Science · IL

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dmitry S Novikov · 2014 to 2026
$19.3M
QUANTITATIVE MRI AND 1H-MRS IN TRAUMATIC BRAIN INJURYR01NS039135 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUI, YVONNE W · 2000 to 2017
$10.1M
Hippocampal Inflammation as a Pathophysiology for PsychosisR01MH110418 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MALASPINA, DOLORES · 2017 to 2021
$3.8M
The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum DisordersR01MH108962 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LAZAR, MARIANA · 2016 to 2020
$2.5M
Spectroscopic imaging of human epilepsyR01NS090417 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAN, JULLIE W · 2014 to 2017
$2.4M
Quantitative Sodium MR Imaging and Proton MR Spectroscopy in Traumatic Brain InjuryR01NS097494 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIROV, IVAN IVANOV, MADELIN, GUILLAUME · 2016 to 2020
$2.4M
Advanced Software for MRI, PET, SPECT and CT Image AnalysisU24EB028980 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUSINEK, HENRY · 2019 to 2021
$1.2M
NIBIB NIH HHS P41 EB017183NIBIB NIH HHS U24 EB028980NIMH NIH HHS R01 MH108962NIMH NIH HHS R01 MH110418NINDS NIH HHS R01 NS039135NINDS NIH HHS R01 NS090417NINDS NIH HHS R01 NS097494
6 · The paper itself

Abstract

background3D brain proton MR spectroscopic imaging ( PURPOSE: To determine if: 1) white matter (WM) damage in mild traumatic brain injury (mTBI) is homogeneously diffuse, or if specific regions are more affected; 2) partial-volume-corrected, structure-specific STUDY TYPE: Retrospective cross-sectional cohort study. POPULATION: Twenty-seven subjects: 15 symptomatic mTBI patients, 12 matched controls. FIELD STRENGTH/SEQUENCE: 3T using 3D ASSESSMENT: N-acetyl-aspartate (NAA), creatine, choline, and myo-inositol concentrations estimated in predominantly WM regions: body, genu, and splenium of the corpus callosum, corona radiata, frontal, and occipital WM. STATISTICAL TESTS: Analysis of covariance (ANCOVA) to compare patients with controls in terms of regional concentrations. The effect sizes (Cohen's d) of the mean differences were compared across regions and with previously published global data obtained with linear regression of the WM over the entire VOI in the same dataset.

resultsDespite patients' global VOI WM NAA being significantly lower than the controls', no regional differences were observed for any metabolite. Regional NAA comparisons, however, were all unidirectional (patients' NAA concentrations < controls') within a narrow range: 0.3 ≤ Cohen's d ≤ 0.6. DATA

conclusionSince the patient group was symptomatic and exhibiting global WM NAA deficits, these findings suggest: 1) diffuse axonal mTBI damage; that is 2) below the LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:1424-1432.

Indexed as

AdolescentAdultBrain Injuries, TraumaticCase-Control StudiesCross-Sectional StudiesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedProton Magnetic Resonance SpectroscopyRetrospective StudiesWhite MatterYoung Adulthuman studiesMR spectroscopymultivoxel MRStraumatic brain injurywhite matter

Identifiers

PMID30868703
PMCPMC6744359
OpenAlexW2922305098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.