ArticleDevelopmental psychobiology2019
Prenatal exposure to tobacco and marijuana and child autonomic regulation and reactivity: An analysis of indirect pathways via maternal psychopathology and parenting.
Article in Developmental psychobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Birth, cognitive and behavioral effects of intrauterine cannabis exposure in infants and children: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2024Pooled it
- Parenting as a Mediator of Associations between Depression in Mothers and Children's Functioning: A Systematic Review and Meta-Analysis.Clinical child and family psychology review · 2020Pooled it
- Effects of an attachment-based intervention on autonomic regulation among opioid-exposed infants.Developmental psychobiology · 2022Trial
- Prenatal substance exposure and early childhood adversity: implications for child autonomic functioning at early school-age.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Prenatal and Postnatal Exposure to Tobacco and Cannabis and Child Aggression at Early School Age: Role of Early Maternal Sensitivity.Child psychiatry and human development · 2026Article
- Developmental Cascades From Prenatal Tobacco, Tobacco-cannabis Co-exposure to Early school-age externalizing Problems.Research on child and adolescent psychopathology · 2026Article
- A systematic review investigating prenatal cannabis and tobacco co-exposure: Impacts on neonatal, behavioral, cognitive and physiological outcomes.Drug and alcohol dependence reports · 2025Review
- Perceptions of Infant Cry Sounds Among Tobacco and Cannabis Using Mothers and Their Association with Tobacco and Cannabis Cravings.Children (Basel, Switzerland) · 2025Article
- Article
- Cannabis Use during Pregnancy: An Update.Medicina (Kaunas, Lithuania) · 2024Review
- Prenatal tobacco, tobacco-cannabis coexposure, and child emotion regulation: The role of child autonomic functioning and sensitive parenting.Developmental psychology · 2024Article
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Long-term effects of prenatal cannabis exposure: Pathways to adolescent and adult outcomes.Pharmacology, biochemistry, and behavior · 2022Review
- Tobacco and Nervous System Development and Function-New Findings 2015-2020.Brain sciences · 2021Review
- Consequences of Perinatal Cannabis Exposure.Trends in neurosciences · 2019Review
- Prenatal tobacco and marijuana co-use: Sex-specific influences on infant cortisol stress response.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We examined a conceptual model for the associations of prenatal exposure to tobacco (PTE) and marijuana with child reactivity/regulation at 16 months of age. We hypothesized that PTE would be associated with autonomic reactivity and regulation that these associations would be indirect via maternal anger/hostility, depression/stress, or harsh parenting assessed at 2 months and that these effects would be most pronounced among children exposed to both tobacco and marijuana (PTME). Participants were 247 dyads (81 PTE, 97 PTME, and 69 nonexposed) who were followed up at 2 (N = 247) and 16 months (N = 238) of child age. Results from model testing indicated an indirect association between PTME and autonomic functioning during the second year of life, which was mediated by harsh parenting during caregiver-infant interactions. This study fills an important gap in the literature on PTE, PTME, and autonomic regulation during the toddler years, highlighting the role of maternal parenting as important intervening variables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.