Evidence map›Paper›PMID 30868543›Full record

ArticleJournal of natural medicines2019

A new 2H-benzindazole compound from Alternaria alternata Shm-1, an endophytic fungus isolated from the fresh wild fruit of Phellinus igniarius.

Xiuli Wu, Sa Wang, Cheng Liu, Caifang Zhang, Jinjing Guo, Xiaoya Shang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Bioactive Compounds from Medicinal Mushrooms.Advances in biochemical engineering/biotechnology · 2023
    Article
  2. Secondary metabolites ofFrontiers in microbiology · 2022
    Review
  3. Review
  4. Anti-Gout Effects of the Medicinal FungusFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiuli WuCollege of Pharmacy, Ningxia Engineering and Technology Research Center of Modern Hui Medicine, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China. wuxl@nxmu.edu.cn.ORCID http://orcid.org/0000-0002-7089-6530
Sa WangCollege of Pharmacy, Ningxia Engineering and Technology Research Center of Modern Hui Medicine, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China.
Cheng LiuCollege of Pharmacy, Ningxia Engineering and Technology Research Center of Modern Hui Medicine, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China.
Caifang ZhangCollege of Pharmacy, Ningxia Engineering and Technology Research Center of Modern Hui Medicine, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China.
Jinjing GuoCollege of Pharmacy, Ningxia Engineering and Technology Research Center of Modern Hui Medicine, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China.
Xiaoya ShangBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, 100191, People's Republic of China. shangxiaoya@buu.edu.cn.

Funding

National Natural Science Foundation of China 81260477National Natural Science Foundation of China 81560567
6 · The paper itself

Abstract

Endophytic fungi have been shown in recent years to produce a series of bioactive secondary metabolites. Several endophytic fungi were isolated from the fresh wild body of Phellinus igniarius, and initially evaluated for their antimicrobial activity. Among which, Shm-1 extract showed moderate inhibitory activity against Clavibacter michiganense and the fungus was identified to be Alternaria alternata Shm-1 through the comparison of morphological characteristics and the sequence of the rDNA ITS with those of other Alternaria species. A new 2H-benzindazole derivative, alterindazolin A (1), has been isolated from cultures of the endophyte Alternaria alternata Shm-1. Its structure was characterized as 1-benzyl-5-p-hydroxy-phenyloxygen-benz[e]indazole by spectroscopic data analysis including 1D NMR, 2D NMR and MS spectrum.

Indexed as

AlternariaEndophytesFruitHumansMolecular StructureAlterindazolin AAlternaria alternata Shm-1Antibacterial activityPhellinus igniarius

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.