ArticleEndocrine2019
Levothyroxine absorption test results in patients with TSH elevation resistant to treatment.
Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- [Evaluation of sodium levothyroxine absorption in real clinical practice using a single-bolus oral test].Problemy endokrinologii · 2026Article
- Levothyroxine absorption test in patients with refractory hypothyroidism: how to interpret patient's response to the test?Endocrine · 2025Article
- Levothyroxine: Conventional and Novel Drug Delivery Formulations.Endocrine reviews · 2023Review
- Levothyroxine absorption test followed by directly observed treatment on an outpatient basis to address long-term high thyrotropin levels in a hypothyroid patient: a case report.Journal of medical case reports · 2023Article
- Levothyroxine malabsorption or pseudomalabsorption? A question in the management of refractory hypothyroidism.Endocrine connections · 2022Article
- Primary hypothyroidism resolves after switching from L-thyroxine solid tablets to liquid oral substitution. A rare case without evidence of an underlying gastrointestinal malabsorption syndrome.Clinical case reports · 2022Article
- Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review.Endocrine connections · 2020Review
- Levothyroxine Absorption Test - Results and Follow Up of Patients from a Single Center.Indian journal of endocrinology and metabolismArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPersistent elevation of thyroid-stimulating hormone (TSH) is common in endocrinology practice in patients undergoing replacement or suppression therapy with levothyroxine sodium (LT4). After examining the causes of this condition, LT4 absorption test is recommended. In this report, we wanted to share our results of LT4 absorption test in patients with elevated TSH levels. MATERIALS-
methodsThe files of patients who presented to our clinic between 2015 and 2018, whose TSH elevation continued despite high-dose LT4 therapy, and who underwent absorption test were reviewed retrospectively.
resultsLevothyroxine sodium absorption test was applied to five patients. Absorption test revealed LT4 malabsorption in two patients and pseudomalabsorption in the other three patients. DISCUSSION: When all published pseudomalabsorption cases were considered, it has been stated that at least 2.5 times increase in basal fT4 level may exclude malabsorption. The formula we used has been implemented by Cleveland Clinic since 2014.
conclusionIn cases where TSH normalization is not achieved despite high doses of LT4 therapy, LT4 absorption test is an easy test for administration and interpretation and prevents unnecessary medical treatments and examinations.
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