Evidence map›Paper›PMID 30868355›Full record

ArticleJournal of neuro-oncology2019

Fertility treatment is associated with multiple meningiomas and younger age at diagnosis.

Maryam N Shahin, Stephen T Magill, Cecilia L Dalle Ore, Jennifer A Viner, Pamela N Peters, David A Solomon, Michael W McDermott

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maryam N ShahinDepartment of Neurological Surgery, University of California, San Francisco, CA, 94131, USA.
Stephen T MagillDepartment of Neurological Surgery, University of California, San Francisco, CA, 94131, USA. Stephen.magill@ucsf.edu.ORCID http://orcid.org/0000-0002-5257-7835
Cecilia L Dalle OreDepartment of Neurological Surgery, University of California, San Francisco, CA, 94131, USA.
Jennifer A VinerDepartment of Neurological Surgery, University of California, San Francisco, CA, 94131, USA.
Pamela N PetersDepartment of Obstetrics and Gynecology, University of California, San Francisco, CA, 94131, USA.
David A SolomonDepartment of Pathology, University of California, San Francisco, CA, 94131, USA.
Michael W McDermottDepartment of Neurological Surgery, University of California, San Francisco, CA, 94131, USA.
University of California, San Francisco · US

Funding

Development of a molecular diagnostic and prognostic signature for meningiomaF32CA213944 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAGILL, STEPHEN T · 2017 to 2017
$63k
National Cancer Institute 1F32CA213944-01NCI NIH HHS F32 CA213944
6 · The paper itself

Abstract

purposeMeningiomas are more common in females and 70-80% express the progesterone receptor, raising the possibility that high-dose exogenous estrogen/progesterone exposure, such as occurs during fertility treatments, may increase the risk of developing a meningioma. The goal of this study was to report the incidence of prior fertility treatment in a consecutive series of female meningioma patients.

methodsA retrospective review (2015-2018) was performed of female patients with meningioma, and those with prior fertility treatment were compared to those without fertility treatment using standard statistical methods.

resultsOf 206 female patients with meningioma, 26 (12.6%) had a history of fertility treatments. Patients underwent various forms of assisted reproductive technology including: in vitro fertilization (50.0%), clomiphene with or without intrauterine insemination (34.6%), and unspecified (19.2%). Median follow up was 1.8 years. Tumors were WHO grade I (78.6%) or grade II (21.4%). Patients who underwent fertility treatments presented at significantly younger mean age compared to those who had not (51.8 vs. 57.3 years, p = 0.0135, 2-tailed T-test), and on multivariate analysis were more likely to have multiple meningiomas (OR 4.97, 95% CI 1.4-18.1, p = 0.0154) and convexity/falx meningiomas (OR 4.45, 95% CI 1.7-11.5, p = 0.0021).

conclusionsPatients in this cohort with a history of fertility treatment were more likely to present at a younger age and have multiple and convexity/falx meningiomas, emphasizing the importance of taking estrogen/progesterone exposure history when evaluating patients with meningioma. Future clinical studies at other centers in larger populations and laboratory investigations are needed to determine the role of fertility treatment in meningioma development.

Indexed as

Reproductive Techniques, AssistedAdultAgedAge of OnsetClomipheneFemaleFertility Agents, FemaleFollow-Up StudiesHumansInfertility, FemaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm GradingReceptors, EstrogenReceptors, ProgesteroneClomipheneFertility Agents, FemaleReceptors, EstrogenReceptors, ProgesteroneEstrogenFertilityFertility treatmentMeningiomaProgesteroneRisk factor

Identifiers

PMID30868355
PMCPMC6486831
OpenAlexW2922098332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.