Evidence map›Paper›PMID 30868345›Full record

ArticleJournal of clinical monitoring and computing2019

Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia.

Carl Tams, Ken Johnson, Christoph Seubert

Abstract read
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In one paragraph

Article in Journal of clinical monitoring and computing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. End of year summary 2019: anaesthesia and airway management.Journal of clinical monitoring and computing · 2020
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Carl TamsDepartment of Anesthesiology, University of Utah, 30 N 1900 E, Salt Lake City, UT, 84132, USA. carl.tams@utah.edu.ORCID http://orcid.org/0000-0002-2384-5220
Ken JohnsonDepartment of Anesthesiology, University of Utah, 30 N 1900 E, Salt Lake City, UT, 84132, USA.
Christoph SeubertDepartment of Anesthesiology, University of Florida, P.O. Box 100524, Gainesville, FL, 32610-0254, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We implemented a pharmacokinetic/pharmacodynamic (PK/PD) based optimization algorithm recommending intraoperative Remifentanil and Propofol infusion rates to minimize time to emergence and maximize the duration of analgesia in a clinical setting. This feasibility study tested the clinical acceptance of the optimization algorithm's recommendations during scoliosis surgical repair for 14 patients. Anesthesiologist accepted 359/394 (91%) of the recommendations given on the basis of the optimization algorithm. While following the optimization's recommendations the anesthesiologist decreased Propofol infusions from an average of 164-135 mcg/kg/min [p = 0.002] and increased Remifentanil infusions from an average of 0.22-0.30 mcg/kg/min [p = 0.004]. The anesthesiologists appeared to accept and follow the recommendations from a PK/PD based optimization algorithm.

Indexed as

AdolescentAlgorithmsAnalgesics, OpioidAnesthesia Recovery PeriodAnesthesiologyChildComputer GraphicsDecision Support Systems, ClinicalEmergence DeliriumFeasibility StudiesFemaleHumansMalePain ManagementPostoperative PainPostoperative PeriodAnalgesics, OpioidPropofolRemifentanilAnesthesiaIdiopathic scoliosisOptimizationPharmacodynamicPharmacokineticTotal intravenous anesthesia

Identifiers

PMID30868345

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.