ArticleBotanical studies2019
Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis.
Article in Botanical studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 43 citations in OpenAlex.
- Mangrove-associated endomycota: diversity and functional significance as a source of novel drug leads.Archives of microbiology · 2023Review
- Application of Principal Component Analysis (PCA) to the Evaluation and Screening of Multiactivity Fungi.Journal of Ocean University of China : JOUC · 2022Article
- Bioactive Compounds from Mangrove Endophytic Fungus and Their Uses for Microorganism Control.Journal of fungi (Basel, Switzerland) · 2021Review
- Isolation of endophytic fungi with antimicrobial activity from medicinal plant Zanthoxylum simulans Hance.Folia microbiologica · 2021Article
- The complete chloroplast genome ofMitochondrial DNA. Part B, Resources · 2021Article
- Optimal extraction, purification and antioxidant activity of total flavonoids from endophytic fungi ofPeerJ · 2021Article
- Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa.Marine drugs · 2020Review
- Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review.Natural products and bioprospecting · 2019Review
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5 authors at 3 institutions in 1 country.
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Abstract
backgroundAcanthus ilicifolius var. xiamenensis (Acanthaceae) is an old world mangrove species and has long been used as a folk remedy for treating various ailments in traditional medicine. The nature source of A. ilicifolius var. xiamenensis is now in short supply because of the urban development and habitat destruction. To better utilize this resource, biodiversity and bioactivity of endophytic fungi isolated from A. ilicifolius var. xiamenensis were investigated.
resultsA total of 168 fungal isolates were cultured from leaves and stems of the mangrove plant collected in January (winter) and July (summer) 2014 at Kinmen County, Taiwan. Spent culture extract of 28 isolates were found to have bioactivities against one of the following pathogenic microorganisms: the bacteria Bacillus subtilis, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) and the fungi Candida albicans and Cryptococcus neoformans. These positive extracts were mostly active against the Gram-positive bacteria and C. albicans. Corynespora cassiicola NTOU4889 and Xylaria sp. NTOU4900 inhibited growth of all 3 test bacteria whereas Phellinus noxius NTOU4917 inhibited both test fungi. A further anti-inflammatory study of culture extracts of these 28 isolates revealed that extracts with a high iNOS inhibition caused a low viability of cells, and those with a low iNOS inhibition had a high cell viability. Three extracts showed low cytotoxicity (i.e. > 100% cell viability) and high iNOS inhibition (< 15% of NO production) of cells and they were Phoma sp. 2 NTOU4338, Nodulisporium sp. NTOU4868 and Guignardia sp. NTOU4871.
conclusionThese results indicate that the endophytic fungi associated with A. ilicifolius var. xiamenensis can be a potential source of novel natural active substance.
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