ArticleVirchows Archiv : an international journal of pathology2019
Clinicopathological characteristics of thrombospondin type 1 domain-containing 7A-associated membranous nephropathy.
Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and prognosis of malignancy in THSD7A-associated membranous nephropathy: a systematic literature review and clinical case study.Renal failure · 2024Pooled it
- Clinical Features and Pathology of PLA2R and THSD7A-Associated Membranous Nephropathy: A Single-Center Study from China.ImmunoTargets and therapy · 2024Trial
- Questions and Caveats in Antigen-Defined Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2025Review
- Clinicopathological characteristics of neural epidermal growth factor-like 1 protein-associated membranous glomerulonephritis.Virchows Archiv : an international journal of pathology · 2025Article
- Pembrolizumab-Mediated Complete Remission of a PLA2R-Positive Paraneoplastic Membranous Nephropathy: A Case Report.Kidney medicine · 2025Article
- Membranous nephropathy in Kimura disease: A case report and literature review on renal biopsy findings.Clinical nephrology. Case studies · 2025Article
- THSD7A as a Promising Biomarker for Membranous Nephrosis.Molecular biotechnology · 2024Review
- The Prevalence, Characteristics, and Putative Mechanisms of Dual Antigen-Positive Membranous Nephropathy: The Underestimated Condition.International journal of molecular sciences · 2024Review
- Bibliometric and visual analysis of membranous nephropathy literature from 2010 to 2023.Frontiers in pharmacology · 2024Review
- Specific antigens in malignancy-associated membranous nephropathy.Frontiers in medicine · 2024Review
- Analysis of Clinicopathological Characteristics of Malignancy Patients with Membranous Nephropathy and Literature Review.Cancer management and research · 2024Article
- Article
- THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients with Squamous Cell Carcinoma of the Lung.International journal of molecular sciences · 2023Article
- Clinicopathological and prognostic characteristics of idiopathic membranous nephropathy with dual antigen positivity.Frontiers in immunology · 2023Article
- The Role of Anti-PLAInternational journal of environmental research and public health · 2022Review
- Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan.Scientific reports · 2022Article
- The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy.Frontiers in immunology · 2022Article
- Spontaneous Remission of Thrombospondin Type-1 Domain-Containing-Associated Membranous Nephropathy.Internal medicine (Tokyo, Japan) · 2021Article
- Effects of phospholipase AClinical and experimental nephrology · 2021Article
- Bevacizumab-associated glomerular microangiopathy that occurred after postoperative chemotherapy for ovarian cancer.CEN case reports · 2021Article
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Abstract
Thrombospondin type 1 domain-containing 7A (THSD7A) is a recently identified target antigen of idiopathic membranous nephropathy (iMN). The clinicopathological characteristics of THSD7A-associated MN are poorly characterised due to low prevalence among MN patients. Among 469 consecutive cases of pathologically confirmed MN diagnosed at four centres in Japan, 14 cases were confirmed positive for THSD7A by immunohistochemistry (3.0%). The prevalence of THSD7A-associated MN tended to be higher in northern Japan. Most cases demonstrated nephrotic-range proteinuria (12/14 cases, 86%). In two patients, cancer was detected at the time of renal biopsy (small-cell carcinoma of the lung and prostatic adenocarcinoma with neuroendocrine differentiation). Both tumours were negative for THSD7A. Four patients had concurrent or previous incidence of allergic diseases, including one patient with Kimura's disease. Pathological analysis of kidney biopsy tissue revealed slight mesangial cell proliferation in three cases and spike formation in one case. Immunofluorescence studies demonstrated that IgG subclass was mainly IgG4-dominant/codominant (12/13, 92% cases), while the case with prostatic cancer had an IgG2-dominant distribution. The immunostaining profile for components of the lectin complement pathways was not significant in three cases including two patients with malignancy. One case was dual positive for THSD7A and PLA2R. Of 10 cases with known clinical follow-up data, 6 demonstrated reduced serum creatinine and 8 presented reduced proteinuria. In summary, although the major IgG phenotype was usually IgG4-dominant/codominant, clinical background was otherwise heterogeneous. Further investigation of regional differences in THSD7A-associated MN prevalence may reveal genetic and environmental risk factor and associated pathogenic mechanisms.
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