Evidence map›Paper›PMID 30868262›Full record

ArticleMikrochimica acta2019

Fluorometric determination of the activity of the biomarker terminal deoxynucleotidyl transferase via the enhancement of the fluorescence of silver nanoclusters by in-situ grown DNA tails.

Bao-Zhu Chi, Chen-Lu Wang, Zhi-Qiao Wang, Ting Pi, Xiao-Li Zhong, Chao-Qun Deng, Yu-Chuan Feng, Zhi-Mei Li

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bao-Zhu ChiDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Chen-Lu WangDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Zhi-Qiao WangDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Ting PiDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Xiao-Li ZhongDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Chao-Qun DengDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Yu-Chuan FengDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China.
Zhi-Mei LiDepartment of Chemistry, Nanchang University, Nanchang, 330031, People's Republic of China. lizhimei@ncu.edu.cn.

Funding

National Natural Science Foundation of China 21365015Natural Science Foundation of Jiangxi Province (CN) 20171BAB213014
6 · The paper itself

Abstract

The activity of terminal deoxynucleotidyl transferase (TdTase) is a biomarker for routine diagnosis of acute leukemia. A method has been developed for the determination of TdTase activity. It is based on the use of silver nanoclusters (AgNCs) whose yellow fluorescence is enhanced by an in-situ grown DNA tail of TdTase-polymerized and guanine-rich DNA at the 3' end of a hairpin DNA. The fluorescence, best measured at excitation/emission peaks of 530/585 nm, increases linearly in the 1 to 35 mU mL

Indexed as

Base SequenceBiomarkersBiosensing TechniquesDNADNA NucleotidylexotransferaseEnzyme AssaysFluorescenceHumansInverted Repeat SequencesLeukemiaLimit of DetectionMetal NanoparticlesSilverSpectrometry, FluorescenceBiomarkersDNADNA NucleotidylexotransferaseSilverAcute leukemiaAgNCsBiomarkersEnhancement in situFluorescenceGuanine-richHairpin DNALuminescent probesTdTaseTurn on

Identifiers

PMID30868262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.