ArticleRheumatology international2019
Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease.
Article in Rheumatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Biomarkers of kidney involvement in paediatric IgA vasculitis: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- A predictive model based on routine blood inflammatory markers for IgA vasculitis in children.Frontiers in pediatrics · 2026Article
- Association between platelet-to-lymphocyte ratio and blood urea nitrogen levels in pediatric populations: evidence from the NHANES (2009-2018).Translational pediatrics · 2025Article
- Article
- Immunoglobulin a vasculitis with central nervous system involvement: analysis of 10 cases.Clinical and experimental medicine · 2025Article
- Prognostic value of systemic immune-inflammation index and serological biomarkers for deep neck infections.Medicina oral, patologia oral y cirugia bucal · 2024Article
- Assessment of hematologic indices for diagnosis in juvenile systemic lupus erythematosus.Reumatologia · 2024Article
- Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are positively correlated with disease activity of bullous pemphigoid.Archives of dermatological research · 2023Article
- SARS-CoV-2 Infection as a Possible Trigger for IgA-Associated Vasculitis: A Case Report.Children (Basel, Switzerland) · 2023Article
- Severe gastrointestinal involvement in pediatric IgA vasculitis: a retrospective single-center cohort study in China.Frontiers in pediatrics · 2023Article
- Blood routine examination: a simple way for differential diagnosis of immunoglobulin A vasculitis with abdominal involvement and appendicitis in children.Updates in surgery · 2022Article
- Analysis of children with Henoch-Schonlein purpura secondary to infection.Clinical rheumatology · 2022Article
- High levels of plateletZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Lipid metabolism contribute to the pathogenesis of IgA Vasculitis.Diagnostic pathology · 2022Article
- Gastrointestinal involvement in IgA vasculitis: a single-center 11-year study on a cohort of 118 children.Clinical rheumatology · 2021Article
- Differential approach to peripheral blood cell ratios in patients with systemic lupus erythematosus and various manifestations.Rheumatology international · 2020Observational
- Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children.Rheumatology international · 2019Article
- Risk factors for renal involvement in Henoch-Schönlein purpura.Jornal de pediatriaArticle
- Role of Hematological Indices as Predictors of Systemic Inflammation in Dermatology.Indian dermatology online journalReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis in developmental age. The disease is most often characterized by a self-limiting course and good prognosis, but sometimes serious complications, like gastrointestinal bleeding or glomerulonephritis, may develop. The neutrophil to lymphocyte (NLR) and the platelet to lymphocyte (PLR) ratios are indicators related to clinical outcome in various inflammatory diseases. The mean platelet volume to platelet count ratio (MPR) has not been evaluated in patients with IgAV. The aim of this study was to analyze the values of the NLR, PLR and MPR in patients with an acute stage of IgAV compared to healthy children and to assess their suitability for predicting the severity of the disease. All children with IgAV hospitalized in our institution between 2012 and 2017 were reviewed retrospectively. The selected laboratory data were recorded before starting the treatment; these results allowed for NLR, PLR, and MPR calculation. The study involved 71 IgAV children. 57.7% of patients revealed signs of systemic involvement (including GT bleeding and/or glomerulonephritis) and 42.3% were nonsystemic (presenting skin and joint symptoms). 83% of patients were classified as mild and 17% as severe course of the disease. The NLR and the PLR were significantly higher in all IgAV children and in the systemic involvement group in comparison with non-systemic. The MPR was significantly lower in all IgAV group with the exception of children without systemic involvement. The NLR is a more valuable indicator than the PLR to identify patients at higher risk of systemic involvement in the course of IgAV. Clinical usefulness of the MPR requires further research.
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