Evidence map›Paper›PMID 30868222›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2019

Biventricular myocardial strain analysis using cardiac magnetic resonance feature tracking (CMR-FT) in patients with distinct types of right ventricular diseases comparing arrhythmogenic right ventricular cardiomyopathy (ARVC), right ventricular outflow-tract tachycardia (RVOT-VT), and Brugada syndrome (BrS).

Philipp Heermann, H Fritsch, M Koopmann, P Sporns, M Paul, W Heindel, E Schulze-Bahr, C Schülke

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Philipp HeermannCenter of Radiology, Neuroradiology and Nuclear Medicine, Clemens Hospital Muenster, Duesbergweg 124, 48153, Muenster, Germany. philipp.heermann@gmx.de.ORCID http://orcid.org/0000-0003-0655-4218
H FritschInstitute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
M KoopmannDepartment of Cardiology and Angiology, University Hospital Muenster, Muenster, Germany.
P SpornsDepartment of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
M PaulDivision of Cardiology, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
W HeindelDepartment of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
E Schulze-BahrInstitute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
C SchülkeDepartment of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
University Hospital Münster · DEAugenstern · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAs underlying heart diseases of right ventricular tachyarrhythmias, ARVC causes wall-motion abnormalities based on fibrofatty myocardial degeneration, while RVOT-VT and BrS are thought to lack phenotypic MR characteristics. To examine whether cardiac magnetic resonance (CMR) feature tracking (FT) in addition to ARVC objectively facilitates detection of myocardial functional impairments in RVOT-VT and BrS.

methodsCine MR datasets of four retrospectively enrolled, age-matched study groups [n = 65; 16 ARVC, 26 RVOT-VT, 9 BrS, 14 healthy volunteers (HV)] were independently assessed by two distinctly experienced investigators regarding myocardial function using CMR-FT. Global strain (%) and strainrate (s

resultsRV longitudinal and radial basal strain (%) in ARVC (- 12.9 ± 4.2; 11.4 ± 5.1) were significantly impaired compared to RVOT-VT (- 18.0 ± 2.5, p ≤ 0.005; 16.4 ± 5.2, p ≤ 0.05). Synergistically, RVOT endocardial radial strain (%) in ARVC (33.8 ± 22.7) was significantly lower (p ≤ 0.05) than in RVOT-VT (54.3 ± 14.5). For differentiation against BrS, RV basal and medial radial strain values (%) (13.3 ± 6.1; 11.8 ± 2.9) were significantly reduced when compared to HV (21.0 ± 6.9, p ≤ 0.05; 20.1 ± 6.6, p ≤ 0.005), even in case of a normal RV ejection fraction (EF) (> 45%; n = 6) (12.0 ± 2.7 vs. 20.1 ± 6.6, p ≤ 0.05).

conclusionsCMR-FT facilitates relevant differentiation in patients with right ventricular tachyarrhythmias: between ARVC against RVOT-VT and HV as well as between BrS with even a preserved EF against HV.

Indexed as

Arrhythmogenic Right Ventricular DysplasiaBrugada SyndromeDiagnosis, DifferentialElectrocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardial ContractionMyocardiumReproducibility of ResultsRetrospective StudiesVentricular Dysfunction, RightArrhythmogenic right ventricular cardiomyopathy (ARVC)Brugada syndrome (BrS)Feature tracking (FT)Myocardial strain analysisRight ventricular outflow tract tachycardia (RVOT-VT)

Identifiers

PMID30868222
OpenAlexW2922223639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.