Evidence map›Paper›PMID 30868220›Full record

ArticleJournal of neurology2019

Prognostic significance of body weight variation after diagnosis in ALS: a single-centre prospective cohort study.

Toshio Shimizu, Yuki Nakayama, Chiharu Matsuda, Michiko Haraguchi, Kota Bokuda, Kazuko Ishikawa-Takata, Akihiro Kawata, Eiji Isozaki

Abstract read
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In one paragraph

Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  20. Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Toshio ShimizuDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan. toshio_shimizu@tmhp.jp.ORCID http://orcid.org/0000-0002-3828-9669
Yuki NakayamaALS Nursing Care Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Chiharu MatsudaALS Nursing Care Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Michiko HaraguchiALS Nursing Care Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kota BokudaDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan.
Kazuko Ishikawa-TakataDepartment of Nutritional Education, National Institute of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
Akihiro KawataDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan.
Eiji IsozakiDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan.
Tokyo Metropolitan Neurological Hospital · JPTokyo Metropolitan Institute of Medical Science · JPNational Institute of Biomedical Innovation, Health and Nutrition · JP

Funding

Japan Society for the Promotion of Science 16H03044Japan Society for the Promotion of Science 16H05583Japan Society for the Promotion of Science 25293449
6 · The paper itself

Abstract

backgroundBody weight reduction after disease onset is an independent predictor of survival in amyotrophic lateral sclerosis (ALS), but significance of weight variation after diagnosis remains to be established.

objectiveTo investigate weight variation after diagnosis and its prognostic significance in patients with ALS as a prospective cohort study.

methodsSeventy-nine patients with ALS were enrolled in this study. At the time of diagnosis and about 1 year later, we evaluated the following parameters: age, sex, onset age, onset region, body mass index (BMI) and premorbid BMI, forced vital capacity and the revised ALS functional rating scale. Annual BMI decline rates (∆BMI) from onset to diagnosis and from diagnosis to about 1 year later were calculated. Patients were followed to the endpoints (death or tracheostomy), and the relationships between ∆BMIs and survival were investigated.

resultsPatients with post-diagnostic ∆BMI ≥ 2.0 kg/m

conclusionBody weight changes after diagnosis strongly predicts survival in ALS, and weight gain after diagnosis may improve survival prognosis, particularly in female ALS patients.

Indexed as

Body Mass IndexAdultAgedAmyotrophic Lateral SclerosisFemaleHumansMaleMiddle AgedPrognosisProspective StudiesSex FactorsWeight GainWeight LossAmyotrophic lateral sclerosisBody weightNutritional interventionSex differenceSurvival

Identifiers

PMID30868220
OpenAlexW2920918570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.